Citation: Wang Hechen, Li Tianjiao, Bao Yongrui, Wang Shuai, Meng Xiansheng. A multifunctional integrated simultaneously online screening microfluidic biochip for the examination of "efficacy-toxicity" and compatibility of medicine[J]. Chinese Chemical Letters, ;2019, 30(2): 403-405. doi: 10.1016/j.cclet.2018.08.016 shu

A multifunctional integrated simultaneously online screening microfluidic biochip for the examination of "efficacy-toxicity" and compatibility of medicine

Wang Hechen ^a ,
Li Tianjiao ^a,b ,
Bao Yongrui ^a,b ,
Wang Shuai ^a,b ,
Meng Xiansheng ^a,b,*,

a.
College of Liaoning University of Traditional Chinese Medicine, Dalian 116600, China
b.
Liaoning University of Traditional Chinese Medicine-Agilent Technologies Modern TCM and Multi-Omics Research Collaboration Lab, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China

mxsvvv@163.com

Received Date: 30 May 2018
Revised Date: 30 July 2018
Accepted Date: 28 August 2018
Available Online: 28 February 2018

Figures(3)

A multifunctional integrated microfluidic biochip device was engineered to estimate the activity-toxicity and composition principle of medicine in a cell model in vitro. This biochip could be used for disease cells and healthy cells in two modules of "Yin-Yang" on the same chip for detecting the medicine efficacytoxicity simultaneously, as well as adjust different gradient ratios of concentration through the Christmas tree structure in both "Yin-Yang" modules autonomously for detecting the best compatibility of medicine in maximum efficacy and minimal toxicity. In the applicability experiment, the best concentration of three chemical compounds including dinatin, diosmetin and cisplatin, were detected using the biochip and traditional 96-cell plate. Biochip assays showed perfect positive correlation compared with the results of traditional 96-cell plate, in addition presented advantages as less detection time and much lower price than the traditional 96-cell plate, which indicated the biochip is both convenient and feasible. Thus, the novel microfluidic chip-based multifunctional integrated system congregated the virtues of high throughput, rapid, sensitive, specific, cost-effective, and similar to the physical environment of the human body, which was especially suitable for the medicine efficacy-toxicity and compatibility evaluation.
- Multifunctional integrated microfluidic,
- biochip,
- Cirsium setosum (Wild.),
- Efficacy-toxicity of medicines,
- Compatibility of medicines,
- Simultaneously online screening
1. [1]
  J.Tao, J.Xu, F.Chen, et al., Eur.J.Pharm.Sci.111(2018) 540-548. doi: 10.1016/j.ejps.2017.10.039
2. [2]
  Y.Ma, Y.Bao, S.Wang, et al., Inflammation 39(2016) 1453-1461. doi: 10.1007/s10753-016-0377-4
3. [3]
  Y.Wang, Z.Sun, M.Szyf, Oncotarget 8(2017) 111866-111881.
4. [4]
  J.M.McKim Jr, H.Baas, G.P.Rice, et al., Food Chem.Toxicol.96(2016) 1-10. doi: 10.1016/j.fct.2016.07.006
5. [5]
  A.Falanga, M.Marchetti, Thromb.Res.164(2018)S54-S61. doi: 10.1016/j.thromres.2018.01.017
6. [6]
  M.T.Abreu, P.Vora, E.Faure, et al., J.Immunol.167(2001) 1609-1616. doi: 10.4049/jimmunol.167.3.1609
7. [7]
  N.C.A.van Engeland, A.M.A.O.Pollet, J.M.J.den Toonder, et al., Lab Chip 18(2018) 1607-1620. doi: 10.1039/C8LC00286J
8. [8]
  H.Zhang, L.Xiao, Q.Li, et al., Biomicrofluidics 12(2018) 024119-024124. doi: 10.1063/1.5024359
9. [9]
  M.Oshiki, T.Miura, S.Kazama, et al., Front.Microbiol.27(2018) 830.
10. [10]
  C.P.Miller, C.Tsuchida, Y.Zheng, et al., Neoplasia 20(2018) 610-620. doi: 10.1016/j.neo.2018.02.011
11. [11]
  S.N.Bhatia, D.E.Ingber, Nat.Biotechnol.32(2014) 760-772. doi: 10.1038/nbt.2989
12. [12]
  Y.Liu, X.Jiang, Lab Chip 17(2017) 3960-3978. doi: 10.1039/C7LC00627F
13. [13]
  J.Fan, Y.Bao, X.Meng, et al., Oncotarget 19(2017) 31395-31405.
14. [14]
  J.Chamoun, A.Pattekar, F.Afshinmanesh, et al., Lab Chip 18(2018) 1581-1592. doi: 10.1039/C7LC01266G
15. [15]
  F.Zarghampour, Y.Yamini, M.Baharfar, M.Faraji, J.Chromatogr.A 1556(2018) 21-28. doi: 10.1016/j.chroma.2018.04.046
16. [16]
  A.Bein, W.Shin, S.J.Firoozinezhad, et al., Cell.Mol.Gastroenterol.Hepatol.5(2018) 659-668. doi: 10.1016/j.jcmgh.2017.12.010
17. [17]
  S.Han, J.Kim, R.Li, et al., Adv.Healthc.Mater.7(2018) 1800122. doi: 10.1002/adhm.v7.12
18. [18]
  Y.Zhang, Z.Wang, L.Wu, et al., Small 14(2018) 1704433-1704436. doi: 10.1002/smll.v14.20
19. [19]
  X.Li, X.Ying, H.Yan, et al., Chin.Pharm.J.10(2017) 1624-1628.
20. [20]
  C.Song, B.Shen, S.Zhu, et al., J.Clin.Emergency 4(2017)
1. [1]
  Linzhou Yin , Xiaowen Jiang , Miao Wang , Yiren Yang , Zhonggui He , Jin Sun , Huiyuan Gao , Mengchi Sun . Phytoconstituent-derived nano-medicines/vesicles providing a promising dawn for inflammatory bowel disease. Chinese Chemical Letters, 2025, 36(6): 110224-. doi: 10.1016/j.cclet.2024.110224
2. [2]
  Zhenxing Li , Yue Ding , Xinxin Tuo , Jinhong Hu , Taihong Zhang , Xiang Zhou , Liwei Liu , Song Yang . Structure-based drug repurposing targeting pathogenic virus superfamily 1 helicase: An integrated multi-computational screening and bioactivity identification strategy. Chinese Chemical Letters, 2025, 36(9): 110737-. doi: 10.1016/j.cclet.2024.110737
3. [3]
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4. [4]
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5. [5]
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6. [6]
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7. [7]
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8. [8]
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9. [9]
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10. [10]
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11. [11]
  Yizhi Ge , Jiahui Zou , Hui Liu , Wei He , Huanfeng Zhu . Cisplatin-polyphenol complex liposomes reduce chemotherapy toxicity. Chinese Chemical Letters, 2026, 37(1): 111450-. doi: 10.1016/j.cclet.2025.111450
12. [12]
  Lei Wang , Jun-Jie Wu , Chang-Cun Yan , Wan-Ying Yang , Zong-Lu Che , Xin-Yu Xia , Xue-Dong Wang , Liang-Sheng Liao . Near-infrared organic lasers with ultra-broad emission bands by simultaneously harnessing four-level and six-level systems. Chinese Chemical Letters, 2024, 35(8): 109365-. doi: 10.1016/j.cclet.2023.109365
13. [13]
  Chunrui Zhao , Tianren Li , Jiage Li , Yansong Liu , Zian Fang , Xinyu Wang , Mingxin Huo , Shuangshi Dong , Mingyu Li . Doped cobalt for simultaneously promoting active (001) facet exposure of MIL-68(In) and acting as reactive sites in peroxymonosulfate-mediated photocatalytic decontamination. Chinese Chemical Letters, 2025, 36(5): 110201-. doi: 10.1016/j.cclet.2024.110201
14. [14]
  Hongmei Yu , Baoxi Zhang , Meiju Liu , Cheng Xing , Guorong He , Li Zhang , Ningbo Gong , Yang Lu , Guanhua Du . Theoretical and experimental cocrystal screening of temozolomide with a series of phenolic acids, promising cocrystal coformers. Chinese Chemical Letters, 2024, 35(5): 109032-. doi: 10.1016/j.cclet.2023.109032
15. [15]
  Feng Wu , Xuemin Kong , Yixuan Liu , Shuli Wang , Zhong Chen , Xu Hou . Microfluidic-based isolation of circulating tumor cells with high-efficiency and high-purity. Chinese Chemical Letters, 2024, 35(8): 109754-. doi: 10.1016/j.cclet.2024.109754
16. [16]
  Jia Chen , Yun Liu , Zerong Long , Yan Li , Hongdeng Qiu . Colorimetric detection of α-glucosidase activity using Ni-CeO₂ nanorods and its application to potential natural inhibitor screening. Chinese Chemical Letters, 2024, 35(9): 109463-. doi: 10.1016/j.cclet.2023.109463
17. [17]
  Beitong Zhu , Xiaorui Yang , Lirong Jiang , Tianhong Chen , Shuangfei Wang , Lintao Zeng . A portable and versatile fluorescent platform for high-throughput screening of toxic phosgene, diethyl chlorophosphate and volatile acyl chlorides. Chinese Chemical Letters, 2025, 36(1): 110222-. doi: 10.1016/j.cclet.2024.110222
18. [18]
  Qingyun Hu , Wei Wang , Junyuan Lu , He Zhu , Qi Liu , Yang Ren , Hong Wang , Jian Hui . High-throughput screening of high energy density LiMn_1-xFe_xPO₄ via active learning. Chinese Chemical Letters, 2025, 36(2): 110344-. doi: 10.1016/j.cclet.2024.110344
19. [19]
  Yao Zou , Difei Gong , Haiguang Yang , Hongmei Yu , Guorong He , Ningbo Gong , Lianhua Fang , Guanhua Du , Yang Lu . Prediction, screening, characterization, antioxidant and antihypoxic effects of multi-component zwitterionic cocrystals of dietary flavonoids with picolinic acid. Chinese Chemical Letters, 2025, 36(9): 110768-. doi: 10.1016/j.cclet.2024.110768
20. [20]
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沈阳化工大学材料科学与工程学院沈阳 110142