Citation: Wu Chunlei, Wang Wei, Fang Lijing, Su Wu. Programmable pyrrole-imidazole polyamides: A potent tool for DNA targeting[J]. Chinese Chemical Letters, ;2018, 29(7): 1105-1112. doi: 10.1016/j.cclet.2018.05.025 shu

Programmable pyrrole-imidazole polyamides: A potent tool for DNA targeting

Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

Corresponding author: Fang Lijing, lj.fang@siat.ac.cn Su Wu, wu.su@siat.ac.cn
Received Date: 9 April 2018
Revised Date: 14 May 2018
Accepted Date: 15 May 2018
Available Online: 17 July 2018

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Hairpin pyrrole-imidazole (Py-Im) polyamides are a class of programmable minor-groove binders that recognize pre-determined DNA double helixes with high affinity and specificity. They are capable of regulating gene expression by modulating the activity of transcription factors. To date, Py-Im polyamides have been successfully applied as a potent tool to disturb DNA functions and considered as a group of promising candidates for the clinical applications. Herein, this review will focus on summarizing the recent advances of Py-Im polyamides from their synthesis to applications via various modifications at the molecular level.
- Py-Im polyamides,
- DNA binding,
- Gene modulation,
- Targeting ligands
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