Citation: Gao Wenxia, Hu Yalong, Xu Long, Liu Miaochang, Wu Huayue, He Bin. Dual pH and glucose sensitive gel gated mesoporous silica nanoparticles for drug delivery[J]. Chinese Chemical Letters, ;2018, 29(12): 1795-1798. doi: 10.1016/j.cclet.2018.05.022 shu

Dual pH and glucose sensitive gel gated mesoporous silica nanoparticles for drug delivery

Gao Wenxia ^a,b ,
Hu Yalong ^b ,
Xu Long ^a ,
Liu Miaochang ^b ,
Wu Huayue ^b,*, ,
He Bin ^a

a.
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
b.
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China

huayuewu@wzu.edu.cn

Received Date: 24 February 2018
Revised Date: 10 April 2018
Accepted Date: 10 May 2018
Available Online: 16 December 2018

Figures(4)

A low molecular weight gelator with dual pH and glucose sensitive moieties was synthesized. The gelator penetrated in the mesopores of silica nanoparticles (MSNs) and formed low molecular weight gel (LMWG) as gate to fabricate dual pH and glucose responsive nano drug delivery system. Antidiabetic drug was loaded in the gel caped MSNs, the drug release was responsive to the pH and glucose levels and the drug release could be controlled via the stimuli sensitivity of gel.
- Low-molecular-weight gel,
- Glucose/pH sensitive,
- Gate controller,
- Mesoporous silica nanoparticles,
- Controlled release
1. [1]
  E. Aznar, M. Oroval, L. Pascual, et al., Chem. Rev. 116(2016) 561-718. doi: 10.1021/acs.chemrev.5b00456
2. [2]
  Z.X. Li, J.C. Barnes, A. Bosoy, J.F. Stoddart, J.I. Zink, Chem. Soc. Rev. 41(2012) 2590-2605. doi: 10.1039/c1cs15246g
3. [3]
  R. Bhat, A. Ribes, N. Mas, et al., Langmuir 32(2016) 1195-1200. doi: 10.1021/acs.langmuir.5b04038
4. [4]
  Y. Chang, X. Liu, Q. Zhao, et al., Chin. Chem. Lett. 26(2015) 1203-1208. doi: 10.1016/j.cclet.2015.08.005
5. [5]
  N. Song, Y.W. Yang, Chem. Soc. Rev. 44(2015) 3474-3504. doi: 10.1039/C5CS00243E
6. [6]
  A.A. Hwang, J. Lu, F. Tamanoi, J.I. Zink, Small 11(2015) 319-328. doi: 10.1002/smll.v11.3
7. [7]
  L. Zhang, Y. Li, J.C. Yu, J. Mater. Chem. B 2(2014) 452-470. doi: 10.1039/C3TB21196G
8. [8]
  Q. Zhang, Z. Ye, S. Wang, J. Yin, Chin. Chem. Lett. 25(2014) 257-260. doi: 10.1016/j.cclet.2013.11.002
9. [9]
  S. Baek, R.K. Singh, D. Khanal, et al., Nanoscale 7(2015) 14191-14216. doi: 10.1039/C5NR02730F
10. [10]
  S.A. Mackowiak, A. Schmidt, V. Weiss, et al., Nano Lett. 13(2013) 2576-2583. doi: 10.1021/nl400681f
11. [11]
  D. Wang, S. Wu, Langmuir 32(2016) 632-636. doi: 10.1021/acs.langmuir.5b04399
12. [12]
  S.W. Zhou, X.Z. Du, F.B. Cui, X.F. Zhang, Small 10(2014) 980-988. doi: 10.1002/smll.201302312
13. [13]
  J.G. Croissanta, D. Zhang, S. Alsaiari, et al., J. Control Release 229(2016) 183-191. doi: 10.1016/j.jconrel.2016.03.030
14. [14]
  Y. Zhang, C.Y. Ang, M. Li, et al., ACS Appl. Mater. Interfaces 7(2015) 18179-18187. doi: 10.1021/acsami.5b05893
15. [15]
  J. Lee, E. Oh, H. Yoon, et al., Nanoscale 8(2016) 8070-8077. doi: 10.1039/C5NR09280A
16. [16]
  C.L. Zhu, C.H. Lu, X.Y. Song, H.H. Yang, X.R. Wang, J. Am. Chem. Soc. 133(2011) 1278-1281. doi: 10.1021/ja110094g
17. [17]
  T. Chen, W. Wu, H. Xiao, et al., ACS Macro Lett. 5(2016) 55-58. doi: 10.1021/acsmacrolett.5b00765
18. [18]
  C. Yu, L. Qian, J. Ge, et al., Angew. Chem. Int. Ed. 55(2016) 9272-9276. doi: 10.1002/anie.201602188
19. [19]
  Y. Li, W. Xiao, K. Xiao, et al., Angew. Chem. Int. Ed. 124(2012) 2918-2923. doi: 10.1002/ange.201107144
20. [20]
  Y. Zhou, X. Li, Chin. Chem. Lett. 28(2017) 1835-1840. doi: 10.1016/j.cclet.2017.04.033
21. [21]
  B.O. Okesola, D.K. Smith, Chem. Soc. Rev. 45(2016) 4226-4251. doi: 10.1039/C6CS00124F
22. [22]
  E.R. Draper, D.J. Adams, Chem. Commun. 52(2016) 8196-8206. doi: 10.1039/C6CC03485C
23. [23]
  Z. Zou, D. He, L. Cai, et al., ACS Appl. Mater. Interfaces 8(2016) 8358-8366. doi: 10.1021/acsami.5b12576
24. [24]
  D. Shi, M. Ran, L. Zhang, et al., ACS Appl. Mater. Interfaces 8(2016) 13688-13697. doi: 10.1021/acsami.6b02121
25. [25]
  L. Tan, M. Yang, H. Wu, et al., ACS Appl. Mater. Interfaces 7(2015) 6310-6316. doi: 10.1021/acsami.5b00631
26. [26]
  L. Zhao, C. Xiao, L. Wang, G. Gaia, J. Ding, Chem. Commun. 52(2016) 7633-7652. doi: 10.1039/C6CC02202B
27. [27]
  P. Diez, A. Sanchez, C. de la Torre, et al., ACS Appl. Mater. Interfaces 8(2016) 7657-7665. doi: 10.1021/acsami.5b12645
28. [28]
  S. Pan, S. Luo, S. Li, et al., Chem. Commun. 49(2013) 8045-8047. doi: 10.1039/c3cc44767g
29. [29]
  C. Zhou, W. Gao, K. Yang, et al., Langmuir 29(2013) 13568-13575. doi: 10.1021/la4033578
1. [1]
  Jiaxu Wang , Jinxie Zhang , Xiuping Wang , Jingying Wang , Lina Chen , Jiahui Cao , Wei Cao , Siyu Liang , Ping Luan , Ke Zheng , Xiao-Kun Ouyang , Li Gao , Xiaowen Ou , Fan Zhang , Meitong Ou , Lin Mei . CaCO₃-coated hollow mesoporous silica nanoparticles for pH-responsive fungicides release. Chinese Chemical Letters, 2024, 35(12): 109697-. doi: 10.1016/j.cclet.2024.109697
2. [2]
  Hualei Xu , Manman Han , Haiqiang Liu , Liang Qin , Lulu Chen , Hao Hu , Ran Wu , Chenyu Yang , Hua Guo , Jinrong Li , Jinxiang Fu , Qichen Hao , Yijun Zhou , Jinchao Feng , Xiaodong Wang . 4-Nitrocatechol as a novel matrix for low-molecular-weight compounds in situ detection and imaging in biological tissues by MALDI-MSI. Chinese Chemical Letters, 2024, 35(6): 109095-. doi: 10.1016/j.cclet.2023.109095
3. [3]
  Yue Ren , Kang Li , Yi-Zi Wang , Shao-Peng Zhao , Shu-Min Pan , Haojie Fu , Mengfan Jing , Yaming Wang , Fengyuan Yang , Chuntai Liu . Swelling and erosion assisted sustained release of tea polyphenol from antibacterial ultrahigh molecular weight polyethylene for joint replacement. Chinese Chemical Letters, 2025, 36(2): 110468-. doi: 10.1016/j.cclet.2024.110468
4. [4]
  Wen Zhong , Dan Zheng , Xukun Liao , Yadi Zhou , Yan Jiang , Ting Gao , Ming Li , Chengli Yang . Elaborate construction of pH-sensitive polymyxin B loaded nanoparticles for safe and effective treatment of carbapenem-resistant Klebsiella pneumoniae. Chinese Chemical Letters, 2025, 36(3): 110448-. doi: 10.1016/j.cclet.2024.110448
5. [5]
  Feng Cui , Fangman Chen , Xiaochun Xie , Chenyang Guo , Kai Xiao , Ziping Wu , Yinglu Chen , Junna Lu , Feixia Ruan , Chuanxu Cheng , Chao Yang , Dan Shao . Scalable production of mesoporous titanium nanoparticles through sequential flash nanocomplexation. Chinese Chemical Letters, 2024, 35(4): 108681-. doi: 10.1016/j.cclet.2023.108681
6. [6]
  Zhaomin Tang , Qian He , Jianren Zhou , Shuang Yan , Li Jiang , Yudong Wang , Chenxing Yao , Huangzhao Wei , Keda Yang , Jiajia Wang . Active-transporting of charge-reversal Cu(Ⅱ)-doped mesoporous silica nanoagents for antitumor chemo/chemodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109742-. doi: 10.1016/j.cclet.2024.109742
7. [7]
  Jichun Li , Zhengren Wang , Yu Deng , Hongxiu Yu , Yonghui Deng , Xiaowei Cheng , Kaiping Yuan . Construction of mesoporous silica-implanted tungsten oxides for selective acetone gas sensing. Chinese Chemical Letters, 2024, 35(11): 110111-. doi: 10.1016/j.cclet.2024.110111
8. [8]
  Yuwen Zhu , Xiang Deng , Yan Wu , Baode Shen , Lingyu Hang , Yuye Xue , Hailong Yuan . Formation mechanism of herpetrione self-assembled nanoparticles based on pH-driven method. Chinese Chemical Letters, 2025, 36(1): 109733-. doi: 10.1016/j.cclet.2024.109733
9. [9]
  Pei Cao , Yilan Wang , Lejian Yu , Miao Wang , Liming Zhao , Xu Hou . Dynamic asymmetric mechanical responsive carbon nanotube fiber for ionic logic gate. Chinese Chemical Letters, 2024, 35(6): 109421-. doi: 10.1016/j.cclet.2023.109421
10. [10]
  Wantong Zhang , Zixing Xu , Guofei Dai , Zhijian Li , Chunhui Deng . Removal of Microcystin-LR in lake water sample by hydrophilic mesoporous silica composites under high-throughput MALDI-TOF MS detection platform. Chinese Chemical Letters, 2024, 35(5): 109135-. doi: 10.1016/j.cclet.2023.109135
11. [11]
  Guorong Li , Yijing Wu , Chao Zhong , Yixin Yang , Zian Lin . Predesigned covalent organic framework with sulfur coordination: Anchoring Au nanoparticles for sensitive colorimetric detection of Hg(Ⅱ). Chinese Chemical Letters, 2024, 35(5): 108904-. doi: 10.1016/j.cclet.2023.108904
12. [12]
  Xiangqian Cao , Chenkai Yang , Xiaodong Zhu , Mengxin Zhao , Yilin Yan , Zhengnan Huang , Jinming Cai , Jingming Zhuang , Shengzhou Li , Wei Li , Bing Shen . Synergistic enhancement of chemotherapy for bladder cancer by photothermal dual-sensitive nanosystem with gold nanoparticles and PNIPAM. Chinese Chemical Letters, 2024, 35(8): 109199-. doi: 10.1016/j.cclet.2023.109199
13. [13]
  Tingting Hu , Chao Shen , Xueyan Wang , Fengbo Wu , Zhiyao He . Tumor microenvironment-sensitive polymeric nanoparticles for synergetic chemo-photo therapy. Chinese Chemical Letters, 2024, 35(11): 109562-. doi: 10.1016/j.cclet.2024.109562
14. [14]
  Ke Wang , Jia Wu , Shuyi Zheng , Shibin Yin . NiCo Alloy Nanoparticles Anchored on Mesoporous Mo2N Nanosheets as Efficient Catalysts for 5-Hydroxymethylfurfural Electrooxidation and Hydrogen Generation. Chinese Journal of Structural Chemistry, 2023, 42(10): 100104-100104. doi: 10.1016/j.cjsc.2023.100104
15. [15]
  Zhuo Li , Peng Yu , Di Shen , Xinxin Zhang , Zhijian Liang , Baoluo Wang , Lei Wang . Low-loading Pt anchored on molybdenum carbide-based polyhedral carbon skeleton for enhancing pH-universal hydrogen production. Chinese Chemical Letters, 2025, 36(4): 109713-. doi: 10.1016/j.cclet.2024.109713
16. [16]
  Xiao-Fang Lv , Xiao-Yun Ran , Yu Zhao , Rui-Rui Zhang , Li-Na Zhang , Jing Shi , Ji-Xuan Xu , Qing-Quan Kong , Xiao-Qi Yu , Kun Li . Combing NIR-Ⅱ molecular dye with magnetic nanoparticles for enhanced photothermal theranostics with a 95.6% photothermal conversion efficiency. Chinese Chemical Letters, 2025, 36(4): 110027-. doi: 10.1016/j.cclet.2024.110027
17. [17]
  Yutong Xiong , Ting Meng , Wendi Luo , Bin Tu , Shuai Wang , Qingdao Zeng . Molecular conformational effects on co-assembly systems of low-symmetric carboxylic acids investigated by scanning tunneling microscopy. Chinese Journal of Structural Chemistry, 2025, 44(2): 100511-100511. doi: 10.1016/j.cjsc.2025.100511
18. [18]
  Hao Wang , Meng-Qi Pan , Ya-Fei Wang , Chao Chen , Jian Xu , Yuan-Yuan Gao , Chuan-Song Qi , Wei Li , Xian-He Bu . Post-synthetic modifications of MOFs by different bolt ligands for controllable release of cargoes. Chinese Chemical Letters, 2024, 35(10): 109581-. doi: 10.1016/j.cclet.2024.109581
19. [19]
  Zheyi Li , Xiaoyang Liang , Zitong Qiu , Zimeng Liu , Siyu Wang , Yue Zhou , Nan Li . Ion-interferential cell cycle arrest for melanoma treatment based on magnetocaloric bimetallic-ion sustained release hydrogel. Chinese Chemical Letters, 2024, 35(11): 109592-. doi: 10.1016/j.cclet.2024.109592
20. [20]
  Zhixiao Xiong , Shanni Qiu , Yuyu Wang , Houna Duan , Yi Xiao , Yufang Xu , Weiping Zhu , Xuhong Qian . Photocalibrated NO release from the zinc ion fluorescent probe based on naphthalimide and its application in living cells. Chinese Chemical Letters, 2025, 36(4): 110002-. doi: 10.1016/j.cclet.2024.110002

Get Citation

PDF

XML

Metrics

PDF Downloads(5)
Abstract views(924)
HTML views(98)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142