Citation: Tang Jian, Lu Jingxia, Luo Qunfeng, Wang Huan. Discovery and biosynthesis of thioviridamide-like compounds[J]. Chinese Chemical Letters, ;2018, 29(7): 1022-1028. doi: 10.1016/j.cclet.2018.05.004 shu

Discovery and biosynthesis of thioviridamide-like compounds

State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China

Corresponding author: Wang Huan, wanghuan@nju.edu.cn
Received Date: 15 March 2018
Revised Date: 23 April 2018
Accepted Date: 2 May 2018
Available Online: 2 July 2018

Figures(9)

Thioviridamide-like compounds are a unique subfamily of ribosomally synthesized and post-translationally modified peptides and contain characteristic thioamide bonds and S-[(Z)-2-aminovinyl]-Dcysteine (AviCys). Members of this family are active against a number of cancer cell lines. The distribution, biosynthetic machinery and the mode of action of thioviridamide-like compounds remain largely unknown. In this review, we outlined recent advances in the discovery of thioviridamide-like peptide natural products and the effort in the elucidation of their biosynthetic origin.
- Natural products,
- Thioamides,
- RiPPs,
- Biosynthesis
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