Citation: Sun Chenglong, He Jiuming, Wu Hongbo, Song Xiaowei, Li Jiangshuo, Huang Luojiao, Xu Xiaoyu, Wang Manjiangcuo, Zhang Ruiping, Abliz Zeper. A rapid and sensitive UPLC-MS/MS method for quantitative determination of arformoterol in rat plasma, lung and trachea tissues[J]. Chinese Chemical Letters, ;2018, 29(8): 1284-1286. doi: 10.1016/j.cclet.2018.01.015 shu

A rapid and sensitive UPLC-MS/MS method for quantitative determination of arformoterol in rat plasma, lung and trachea tissues

a.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
b.
Beijing Jialin Pharmaceutical Co., Ltd., Beijing 100121, China
c.
Center for Imaging and Systems Biology, Minzu University of China, Beijing 100081, China

Corresponding author: Abliz Zeper, zeper@imm.ac.cn
Received Date: 28 October 2017
Revised Date: 6 January 2018
Accepted Date: 9 January 2018
Available Online: 10 August 2018

Figures(3)

A rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and fully validated for determination of arformoterol in rat plasma, lung and trachea tissues. The chromatographic separation was performed on an Agilent XDB C8 column with gradient elution by using acetonitrile and 0.1% formic acid water. The method presented high sensitivity (LLOQ of 1.83 pg/mL for plasma and 3.90 pg/mL for lung and trachea tissue homogenates) and great linearity over the range of 1.83-458 pg/mL for plasma, 13.9-1560 pg/mL for lung and trachea tissue homogenates. No carry over effect and matrix effect were observed. The intra-and inter-day precision/accuracy were within ±15% at three quality control concentration levels. This robust method was successfully applied to the pharmacokinetic, lung and trachea tissue distribution study after inhalation administration of arformoterol tartrate inhalation solution (50 mg/kg). The in vivo information indicate that arformoterol can be rapidly absorbed into blood through respiratory systems, lung and trachea tissue maintain a certain amount of arformoterol in 1 h after dosing.
- Arformoterol,
- Inhalation administration,
- LC-MS/MS,
- Pharmacokinetic,
- Tissue distribution
1. [1]
  J.L. Lopez-Campos, W. Tan, J.B. Soriano, Respirology 21(2016) 14-23.
2. [2]
  M. Miravitlles, C. Vogelmeier, N. Roche, et al., Respir. J. 47(2016) 625-637. doi: 10.1183/13993003.01170-2015
3. [3]
  M.G. Matera, J. Ora, M. Cazzola, Ther. Clin. Risk Manag. 11(2015) 1805-1811.
4. [4]
  Y.S. Punekar, S.H. Landis, K. Wurst, H. Le, Respir. Res. 16(2015) 141. doi: 10.1186/s12931-015-0295-2
5. [5]
  D. Singh, Br. J. Clin. Pharmacol. 79(2015) 695-708. doi: 10.1111/bcp.12545
6. [6]
  M.C. Miles, J.F. Donohue, J.A. Ohar, Ther. Adv. Respir. Dis. 7(2013) 81-86. doi: 10.1177/1753465812465784
7. [7]
  C.H. Loh, J.F. Donohue, J.A. Ohar, Expert Opin. Drug Saf. 14(2015) 463-472. doi: 10.1517/14740338.2015.998196
8. [8]
  V. Ganapathy, M.D. Stensland, Int. J. Chronic Obstruct. Pulmon. Dis. 12(2017) 1793-1801. doi: 10.2147/COPD
9. [9]
  J. Kharidia, C.M. Fogarty, C.F. Laforce, et al., Pulm. Pharmacol. Ther. 21(2008) 657-662. doi: 10.1016/j.pupt.2008.03.003
10. [10]
  P. Zhao, G. Gao, L. Zhang, et al., J. Pharm. Biomed. Anal. 141(2017) 262-269. doi: 10.1016/j.jpba.2017.03.036
11. [11]
  Y. Liu, X. Xun, J. Yi, Y. Xiang, J. Hua, Chin. Chem. Lett. 28(2017) 1093-1098. doi: 10.1016/j.cclet.2016.11.026
12. [12]
  P. Agent, H. Parrott, Breathe (Sheff) 11(2015) 110-118. doi: 10.1183/20734735.021014
13. [13]
  K. Togami, Y. Kanehira, H. Tada, Biopharm. Drug Dispos. 36(2015) 205-215. doi: 10.1002/bdd.v36.4
14. [14]
  N. Barapatre, P. Symvoulidis, W. Moller, et al., J. Pharm. Biomed. Anal. 102(2015) 129-136. doi: 10.1016/j.jpba.2014.09.001
15. [15]
  O. Gonzalez, M.E. Blanco, G. Iriarte, et al., J. Chromatogr. A 1353(2014) 10-27. doi: 10.1016/j.chroma.2014.03.077
16. [16]
  N. Kadian, K.S. Raju, M. Rashid, et al., J. Pharm. Biomed. Anal. 126(2016) 83-97. doi: 10.1016/j.jpba.2016.03.052
17. [17]
  M. Griese, H.G. Kirmeier, G. Liebisch, et al., PLoS One 10(2015) e0117985. doi: 10.1371/journal.pone.0117985
18. [18]
  K.A. Zemski Berry, R.C. Murphy, B. Kosmider, R.J. Mason, J. Lipid Res. 58(2017) 926-933. doi: 10.1194/jlr.M074955
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1.
沈阳化工大学材料科学与工程学院沈阳 110142