Citation: Hu Yongke, Chen Lei, Li Bindong. Practical CuCl/DABCO/4-HO-TEMPO-catalyzed oxidative synthesis of nitriles from alcohols with air as oxidant[J]. Chinese Chemical Letters, ;2018, 29(3): 464-466. doi: 10.1016/j.cclet.2017.10.036 shu

Practical CuCl/DABCO/4-HO-TEMPO-catalyzed oxidative synthesis of nitriles from alcohols with air as oxidant

School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China

Corresponding author: Li Bindong, libindong@njust.edu.cn

Received Date: 9 September 2017
Revised Date: 14 October 2017
Accepted Date: 27 October 2017
Available Online: 28 March 2017

Figures(3)

A mild and efficient methodology for the direct oxidative synthesis of nitriles from easily available alcohols and aqueous ammonia by employing CuCl/DABCO/4-HO-TEMPO as the catalysts is described. This protocol uses the air as a green oxidant and aqueous ammonia as the nitrogen source at room temperature. A variety of aryl, heterocyclic and allylic alcohols are smoothly converted into the corresponding nitriles in good to excellent yields.
- Nitriles,
- Alcohols,
- Copper,
- 4-HO-TEMPO,
- Aerobic oxidation
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