Citation: Fang Yaning, Jia Jun, Yang Jun, Zheng Junhui, Yi Changqing. Facile preparation of holmium(Ⅲ)-doped carbon nanodots for fluorescence/magnetic resonance dual-modal bioimaging[J]. Chinese Chemical Letters, ;2018, 29(8): 1277-1280. doi: 10.1016/j.cclet.2017.10.023 shu

Facile preparation of holmium(Ⅲ)-doped carbon nanodots for fluorescence/magnetic resonance dual-modal bioimaging

Fang Yaning ^a,1 ,
Jia Jun ^a,1 ,
Yang Jun ^b,1 ,
Zheng Junhui ^b,, ,
Yi Changqing ^a,c,,

a.
Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province, School of Engineering, Sun Yat-sen University, Guangzhou 510006, China
b.
Guangdong General Hospital, Guangzhou 510080, China
c.
Research Institute of Sun Yat-sen University in Shenzhen, Shenzhen 518057, China

Corresponding author: Zheng Junhui, 13610228212@163.com Yi Changqing, yichq@mail.sysu.edu.cn

^**

Received Date: 30 June 2017
Revised Date: 16 October 2017
Accepted Date: 18 October 2017
Available Online: 18 August 2017

Figures(5)

In this work, we report the synthesis of holmium(Ⅲ)-doped carbon nanodots (HoBCDs) as fluorescence/magnetic resonance (FL/MR) dual-modal imaging probes via a facile hydrothermal process using citrate acid (CA), branched-polyethylenimine (BPEI) and diethylenetriamine pentaacetic acid hydrate holmium (Ⅲ) dihydrogen salt (Ho-DTPA) as carbon source, passivating reagent and holmium source, respectively. The thus prepared HoBCDs exhibited ultra-small particle size (~4 nm), high water solubility and bright fluorescence with an absolute quantum yield of 8%. Additionally, grey-scaled T₁-weighted images of HoBCDs solution appeared to be apparently brighter than that of deionized water and un-doped blue carbon nanodots (BCDs) solution. In addition, in vitro toxicity assay validated superior biocompatibility of HoBCDs. Using HeLa cells as models, HoBCDs-treated cells were observed to emit blue fluorescence located both in plasma and nucleus, and presented positive contrast enhancement in T₁-weighted images, suggesting their potentials for practical biomedical applications.
- Carbon dots,
- Holmium,
- Dual-modal imaging,
- Fluorescence imaging,
- Magnetic resonance imaging
1. [1]
  D.E. Lee, H. Koo, I.C. Sun, et al., Chem. Soc. Rev. 41 (2012) 2656-2672. doi: 10.1039/C2CS15261D
2. [2]
  M. Swierczewska, S. Lee, X.Y. Chen, Mol. Imaging 10 (2011) 3-16.
3. [3]
  Y. Xing, J.H. Zhao, P.S. Conti, K. Chen, Theranostics 4 (2014) 290-306. doi: 10.7150/thno.7341
4. [4]
  C. Chen, Z.L. Wu, T.T. Wang, et al., Chin. J. Chem. 28 (2017) 1385-1390.
5. [5]
  W. Song, H.J. Zhang, Y.H. Liu, et al., Chin. J. Chem. 28 (2017) 1675-1680.
6. [6]
  M.C. Rong, K.X. Zhang, Y.R. Wang, X. Chen, Chin. J. Chem. 28 (2017) 1119-1124.
7. [7]
  X. Sun, Y. Lei, Trends Anal. Chem. 89 (2017) 163-180. doi: 10.1016/j.trac.2017.02.001
8. [8]
  Y.P. Shi, Y. Pan, H. Zhang, et al., Biosens. Bioelectron. 56 (2014) 39-45. doi: 10.1016/j.bios.2013.12.038
9. [9]
  S. Srivastava, R. Awasthi, D. Tripathi, et al., Small 8 (2012) 1099-1109. doi: 10.1002/smll.201101863
10. [10]
  S. Sahu, N. Sinha, S.K. Bhutia, M. Majhi, S. Mohapatra, J. Mater. Chem. B 2 (2014) 3799-3808. doi: 10.1039/C3TB21669A
11. [11]
  A.B. Bourlinos, A. Bakandritsos, A. Kouloumpis, et al., J. Mater. Chem. 22 (2012) 23327-23330. doi: 10.1039/c2jm35592b
12. [12]
  H.M. Chen, G.D. Wang, W. Tang, et al., Adv. Mater. 26 (2014) 6761-6766. doi: 10.1002/adma.v26.39
13. [13]
  Y.P. Shi, Y. Pan, J. Zhong, et al., Carbon 93 (2015) 742-750. doi: 10.1016/j.carbon.2015.05.100
14. [14]
  Y. Pan, J. Yang, Y.N. Fang, et al., J. Mater. Chem. B 5 (2017) 92-101.
15. [15]
  F.Y. Du, L.R. Zhang, L. Zhang, et al., Biomaterials 121 (2017) 109-120. doi: 10.1016/j.biomaterials.2016.07.008
16. [16]
  H. Liao, Z.Y. Wang, S. Chen, et al., RSC Adv. 5 (2015) 66575-66581. doi: 10.1039/C5RA09948J
17. [17]
  G.S. Hong, S.O. Diao, A.L. Antaris, H.J. Dai, Chem. Rev. 115 (2015) 10816-10906. doi: 10.1021/acs.chemrev.5b00008
18. [18]
  K. Kattel, C.R. Kim, W. Xu, et al., J. Nanosci. Nanotechnol. 15 (2015) 7311-7316. doi: 10.1166/jnn.2015.10582
19. [19]
  W. Xu, K. Kattel, J.Y. Park, et al., Phys. Chem. Chem. Phys. 14 (2012) 12687-12700. doi: 10.1039/c2cp41357d
20. [20]
  M. Norek, J.A. Peters, Prog. Nucl. Mag. Res. Sp. 59 (2011) 64-82. doi: 10.1016/j.pnmrs.2010.08.002
21. [21]
  G.H. Lee, Y. Chang, J. Korean Phys. Soc. 67 (2015) 44-51. doi: 10.3938/jkps.67.44
22. [22]
  S.W. Zielhuis, J.H. Seppenwoolde, C.J.G. Bakker, et al., J. Biomed. Mater. Res. A. 82A (2007) 892-898. doi: 10.1002/(ISSN)1552-4965
23. [23]
  K. Kattel, J.Y. Park, W.L. Xu, et al., ACS Appl. Mater. Interfaces 3 (2011) 3325-3334. doi: 10.1021/am200437r
24. [24]
  W.L. Xu, B.A. Bony, C.R. Kim, et al., Sci. Rep. 3 (2013) 3210. doi: 10.1038/srep03210
25. [25]
  D.L. Ni, W.B. Bu, S.J. Zhang, et al., Adv. Funct. Mater. 24 (2014) 6613-6620. doi: 10.1002/adfm.v24.42
26. [26]
  D.L. Ni, J.W. Zhang, W.B. Bu, et al., Biomaterials 76 (2016) 218-225. doi: 10.1016/j.biomaterials.2015.10.063
27. [27]
  L. Wang, X. Chen, Y.L. Lu, C.X. Liu, W.S. Yang, Carbon 94 (2015) 472-478. doi: 10.1016/j.carbon.2015.06.084
28. [28]
  Y.Q. Dong, R.X. Wang, G.L. Li, et al., Anal. Chem. 84 (2012) 6220-6224. doi: 10.1021/ac3012126
29. [29]
  Y.Q. Dong, R.X. Wang, H. Li, et al., Carbon 50 (2012) 2810-2815. doi: 10.1016/j.carbon.2012.02.046
30. [30]
  Z.X. Gan, H. Xu, Y.L. Hao, Nanoscale 8 (2016) 7794-7807. doi: 10.1039/C6NR00605A
31. [31]
  Z.M. Zhang, Y. Pan, Y.N. Fang, et al., Nanoscale 8 (2016) 500-507. doi: 10.1039/C5NR06534H
32. [32]
  S.W. Yang, J. Sun, X.B. Li, et al., J. Mater. Chem. A 2 (2014) 8660-8667. doi: 10.1039/c4ta00860j
33. [33]
  C. Oerlemans, P.R. Seevinck, G.H. van de Maat, et al., Acta Biomater. 9 (2013) 4681-4687. doi: 10.1016/j.actbio.2012.08.038
34. [34]
  Y. Pan, Y.P. Shi, J.Y. Chen, et al., Mater. Sci. Eng. C-Mater. Biol. Appl. 69 (2016) 561-568. doi: 10.1016/j.msec.2016.07.019
35. [35]
  Z.M. Zhang, Y.P. Shi, Y. Pan, et al., J. Mater. Chem. B 2 (2014) 5020-5027. doi: 10.1039/C4TB00677A
36. [36]
  O. Boussif, F. Lezoualc'h, M.A. Zanta, et al., Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 7297-7301. doi: 10.1073/pnas.92.16.7297
1. [1]
  Gongcheng Ma , Qihang Ding , Yuding Zhang , Yue Wang , Jingjing Xiang , Mingle Li , Qi Zhao , Saipeng Huang , Ping Gong , Jong Seung Kim . Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide. Chinese Chemical Letters, 2024, 35(9): 109293-. doi: 10.1016/j.cclet.2023.109293
2. [2]
  Qiuye Wang , Yabing Sun , Liangxue Lai , Haijing Cui , Yonglong Ye , Ming Yang , Weihao Zhu , Bo Yuan , Quanliang Mao , Wenzhi Ren , Aiguo Wu . MMP-9-responsive probe for fluorescence-magnetic resonance dual-mode imaging of hepatocellular carcinoma models with different metastatic capacities. Chinese Chemical Letters, 2025, 36(4): 110212-. doi: 10.1016/j.cclet.2024.110212
3. [3]
  Boran Cheng , Lei Cao , Chen Li , Fang-Yi Huo , Qian-Fang Meng , Ganglin Tong , Xuan Wu , Lin-Lin Bu , Lang Rao , Shubin Wang . Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging. Chinese Chemical Letters, 2024, 35(6): 108969-. doi: 10.1016/j.cclet.2023.108969
4. [4]
  Du Liu , Yuyan Li , Hankun Zhang , Benhua Wang , Chaoyi Yao , Minhuan Lan , Zhanhong Yang , Xiangzhi Song . Three-in-one erlotinib-modified NIR photosensitizer for fluorescence imaging and synergistic chemo-photodynamic therapy. Chinese Chemical Letters, 2025, 36(2): 109910-. doi: 10.1016/j.cclet.2024.109910
5. [5]
  Jiao Chen , Zihan Zhang , Guojin Sun , Yudi Cheng , Aihua Wu , Zefan Wang , Wenwen Jiang , Fulin Chen , Xiuying Xie , Jianli Li . Benzo[4,5]imidazo[1,2-a]pyrimidine-based structure-inherent targeting fluorescent sensor for imaging lysosomal viscosity and diagnosis of lysosomal storage disorders. Chinese Chemical Letters, 2024, 35(11): 110050-. doi: 10.1016/j.cclet.2024.110050
6. [6]
  Lijia Xu , Tong Zhong , Wei Zhao , Bing Yao , Lin Ding , Huangxian Ju . Chemoselective labeling-based spermatozoa glycan imaging reveals abnormal glycosylation in oligoasthenotspermia. Chinese Chemical Letters, 2024, 35(4): 108760-. doi: 10.1016/j.cclet.2023.108760
7. [7]
  Meiling Xu , Xinyang Li , Pengyuan Liu , Junjun Liu , Xiao Han , Guodong Chai , Shuangling Zhong , Bai Yang , Liying Cui . A novel and visible ratiometric fluorescence determination of carbaryl based on red emissive carbon dots by a solvent-free method. Chinese Chemical Letters, 2025, 36(2): 109860-. doi: 10.1016/j.cclet.2024.109860
8. [8]
  Rui Cheng , Xin Huang , Tingting Zhang , Jiazhuang Guo , Jian Yu , Su Chen . Solid superacid catalysts promote high-performance carbon dots with narrow-band fluorescence emission for luminescence solar concentrators. Chinese Chemical Letters, 2024, 35(8): 109278-. doi: 10.1016/j.cclet.2023.109278
9. [9]
  Sixin Ai , Wenxiu Li , Huayong Zhu , Yang Wan , Weiying Lin . Viscosity-responsive signal amplification dual-modal probe triggered by cysteine/homocysteine for monitoring diabetic liver damages and repair processes. Chinese Chemical Letters, 2025, 36(3): 109904-. doi: 10.1016/j.cclet.2024.109904
10. [10]
  Shuangying Li , Qingxiang Zhou , Zhi Li , Menghua Liu , Yanhui Li . Sensitive measurement of silver ions in environmental water samples integrating magnetic ion-imprinted solid phase extraction and carbon dot fluorescent sensor. Chinese Chemical Letters, 2024, 35(5): 108693-. doi: 10.1016/j.cclet.2023.108693
11. [11]
  Yiqiao Chen , Ao Liu , Biwen Yang , Zhenzhen Li , Binggang Ye , Zhouyi Guo , Zhiming Liu , Haolin Chen . Photoluminescence and photothermal conversion in boric acid derived carbon dots for targeted microbial theranostics. Chinese Chemical Letters, 2024, 35(9): 109295-. doi: 10.1016/j.cclet.2023.109295
12. [12]
  Fengkai Zou , Borui Su , Han Leng , Nini Xin , Shichao Jiang , Dan Wei , Mei Yang , Youhua Wang , Hongsong Fan . Red-emissive carbon quantum dots minimize phototoxicity for rapid and long-term lipid droplet monitoring. Chinese Chemical Letters, 2024, 35(10): 109523-. doi: 10.1016/j.cclet.2024.109523
13. [13]
  Qiang Fu , Shouhong Sun , Kangzhi Lu , Ning Li , Zhanhua Dong . Boron-doped carbon dots: Doping strategies, performance effects, and applications. Chinese Chemical Letters, 2024, 35(7): 109136-. doi: 10.1016/j.cclet.2023.109136
14. [14]
  Chenghao Liu , Xiaofeng Lin , Jing Liao , Min Yang , Min Jiang , Yue Huang , Zhizhi Du , Lina Chen , Sanjun Fan , Qitong Huang . Carbon dots-based dopamine sensors: Recent advances and challenges. Chinese Chemical Letters, 2024, 35(12): 109598-. doi: 10.1016/j.cclet.2024.109598
15. [15]
  Quan Zhang , Shunjie Xing , Jingqian Han , Li Feng , Jianchun Li , Zhaosheng Qian , Jin Zhou . Organic pollutant sensing for human health based on carbon dots. Chinese Chemical Letters, 2025, 36(1): 110117-. doi: 10.1016/j.cclet.2024.110117
16. [16]
  Yuan Liu , Boyang Wang , Yaxin Li , Weidong Li , Siyu Lu . Understanding excitonic behavior and electroluminescence light emitting diode application of carbon dots. Chinese Chemical Letters, 2025, 36(2): 110426-. doi: 10.1016/j.cclet.2024.110426
17. [17]
  Ting Pan , Dinghu Zhang , Guomei You , Xiaoxia Wu , Chenguang Zhang , Xinyu Miao , Wenzhi Ren , Yiwei He , Lulu He , Yuanchuan Gong , Jie Lin , Aiguo Wu , Guoliang Shao . PD-L1 targeted iron oxide SERS bioprobe for accurately detecting circulating tumor cells and delineating tumor boundary. Chinese Chemical Letters, 2025, 36(1): 109857-. doi: 10.1016/j.cclet.2024.109857
18. [18]
  Jianye Kang , Xinyu Yang , Xuhao Yang , Jiahui Sun , Yuhang Liu , Shutao Wang , Wenlong Song . Carbon dots-enhanced pH-responsive lubricating hydrogel based on reversible dynamic covalent bondings. Chinese Chemical Letters, 2024, 35(5): 109297-. doi: 10.1016/j.cclet.2023.109297
19. [19]
  Rui Cheng , Tingting Zhang , Xin Huang , Jian Yu . Facile synthesis of high-brightness green-emitting carbon dots with narrow bandwidth towards backlight display. Chinese Chemical Letters, 2024, 35(5): 108763-. doi: 10.1016/j.cclet.2023.108763
20. [20]
  Wu-Jian Long , Yang Yu , Chuang He . A novel and promising engineering application of carbon dots: Enhancing the chloride binding performance of cement. Chinese Chemical Letters, 2024, 35(6): 108943-. doi: 10.1016/j.cclet.2023.108943

Get Citation

PDF

XML

Metrics

PDF Downloads(4)
Abstract views(723)
HTML views(11)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142