Citation: Bai Jiao, Guo Feng, Wang Rui, Chen Gang, Li Zhanlin, Shao Meili, Xue Chunmei, Hua Huiming. Asperterzine, a symmetric aromatized derivative of epipolythiodioxopiperazine, from the endophytic fungus Aspergillus terreus PR-P-2[J]. Chinese Chemical Letters, ;2018, 29(3): 535-537. doi: 10.1016/j.cclet.2017.09.006 shu

Asperterzine, a symmetric aromatized derivative of epipolythiodioxopiperazine, from the endophytic fungus Aspergillus terreus PR-P-2

Bai Jiao ^a,b ,
Guo Feng ^a,b ,
Wang Rui ^a,b ,
Chen Gang ^a,b ,
Li Zhanlin ^a,b ,
Shao Meili ^a,b ,
Xue Chunmei ^a,b ,
Hua Huiming ^a,b,*,,

a.
Key Laboratory of Structure-Based Drug Design and Discovery(Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, China
b.
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

Corresponding author: Hua Huiming, huimhua@163.com

Received Date: 18 May 2017
Revised Date: 15 August 2017
Accepted Date: 4 September 2017
Available Online: 6 March 2017

Figures(4)

A new epipolythiodioxopiperazine (ETP), asperterzine (1), along with two known analogs, bisdethiobis (methylthio)-acetylaranotin (2) and bisdethiobis(methylthio)-acetylapoaranotin (3), was isolated from the plant endophytic fungus Aspergillus terreus PR-P-2. The structure elucidation of 1 was accomplished by a combination of spectral methods and electronic circular dichroism (ECD) spectrum. Asperterzine (1) was a symmetric aromatized ETP found as a natural product for the first time. Compounds 2 and 3 showed strong cytotoxicity against HL-60 cell line. The putative biosynthetic pathway of 1 was also detailed in the text.
- Asperterzine,
- Epipolythiodioxopiperazine,
- Plant endophytic fungus,
- Aspergillus terreus,
- Cytotoxicity
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