Citation: Wang Wen-Long, Song Li-Jun, Hu Bo-Chun, Miao Li, Chen Xiao-Yu, Fan Wen-Hua, Yin Xu-Ren, Shen Shuang, Ding Zhao-Feng, Yu Chuan-Xin. Decoquinate derivatives: A new class of potent antischistosomal agents against Schistosoma japonicum[J]. Chinese Chemical Letters, ;2017, 28(7): 1547-1552. doi: 10.1016/j.cclet.2017.03.036 shu

Decoquinate derivatives: A new class of potent antischistosomal agents against Schistosoma japonicum

Wang Wen-Long ^a,b,, ,
Song Li-Jun ^b,1 ,
Hu Bo-Chun ^a,1 ,
Miao Li ^a ,
Chen Xiao-Yu ^a ,
Fan Wen-Hua ^a ,
Yin Xu-Ren ^b ,
Shen Shuang ^b ,
Ding Zhao-Feng ^d ,
Yu Chuan-Xin ^b,c,,

a.
School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China
b.
Key Laboratory of National Health and Family Planning Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China
c.
Medical School, Jiangnan University, Wuxi 214122, China
d.
Suzhou Kemu Veterinary Pharmaceutical Co., Ltd., Meiyan High-technology Development Zone, Suzhou 215225, China

Corresponding author: Wang Wen-Long, wwenlong2011@163.com; wenlongwang@jiangnan.edu.cn Yu Chuan-Xin, chxnyu@163.com

Received Date: 26 December 2016
Revised Date: 27 February 2017
Accepted Date: 26 March 2017
Available Online: 30 July 2017

Figures(7)

Decoquinate (1), an old and inexpensive coccidiostat, exhibited potent antimalarial activity, however, its antischistosomal activity against Schistosoma japonicum has not yet been evaluated. Based on decoquinate, a series of decoquinate derivatives was designed, synthesized, evaluated as a new class of antischistosomal agents against S. japonicum adult worms in vitro. Among them, compound 15 killed 100% of adult S. japonicum in 72 h at the concentration of 10 μmol/L in vitro, exhibited stronger wormkilling activity than PZQ in vitro and could serve as a promising lead compound to develop new antischistosomal agents.
- Decoquinate,
- Derivatives,
- Worm-killing activity,
- Schistosoma japonicum,
- Structure-activity relationships (SARs)
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