Citation: Lu Yuan-Yuan, Gong Xue-Peng, Xue Yong-Bo, Zhu Hu-Cheng, Li Xiao-Nian, Hu Lin-Zhen, Guan Jian-Kun, Zhang Jin-Wen, Du Guang, Zhang Yong-Hui. Two pairs of chlorine-containing phenylpropanoid enantiomers from Acorus tatarinowii[J]. Chinese Chemical Letters, ;2017, 28(7): 1460-1464. doi: 10.1016/j.cclet.2017.03.024 shu

Two pairs of chlorine-containing phenylpropanoid enantiomers from Acorus tatarinowii

a.
Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
b.
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
c.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China
d.
College of Life Science, Hubei University, Wuhan 430062, China

Corresponding author: Zhang Jin-Wen, tjzhangjinwei@163.com Du Guang, tjyxb@sina.com Zhang Yong-Hui, zhangyh@mails.tjmu.edu.cn

Received Date: 1 December 2016
Revised Date: 11 January 2017
Accepted Date: 14 March 2017
Available Online: 18 July 2017

Figures(4)

Two pairs of chlorine-containing phenylpropanoid enantiomers (1a/1b and 2a/2b) were isolated from the rhizomes of Acorus tatarinowii. Interestingly, these optical isomers (1a/1b and 2a/2b) were co-existed in the same plant, which were characterized as the first halogen-containing natural products from the genus Acorus. Their structures and absolute configurations were elucidated by a combination of spectroscopic analysis and a single-crystal X-ray diffraction, assisted by a modified Mosher's method. The phenylpropanoid isomers (1a/1b and 2a/2b) were evaluated for their antioxidant activities using DPPH assay and cytotoxic activities against five human cancer cell lines.
- Acorus tatarinowii,
- Chlorine-containing phenylpropanoid,
- Enantiomers,
- Antioxidant activity,
- Cytotoxicity
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1.
沈阳化工大学材料科学与工程学院沈阳 110142