Citation: Liu Rui, Zou Hui, Xu Ping-Sheng, Zou Zhen-Xing, Li Jing, Cheng Fei, Liu Rui-Huan, Zhou Gan, Xu Kang-Ping, Tan Gui-Shan. Uncinatic acids A-C, three new carboxylated flavonoids from Selaginella uncinata[J]. Chinese Chemical Letters, ;2017, 28(7): 1465-1468. doi: 10.1016/j.cclet.2017.03.004 shu

Uncinatic acids A-C, three new carboxylated flavonoids from Selaginella uncinata

Liu Rui ^a,b ,
Zou Hui ^a,b ,
Xu Ping-Sheng ^a ,
Zou Zhen-Xing ^a ,
Li Jing ^b ,
Cheng Fei ^a ,
Liu Rui-Huan ^b ,
Zhou Gan ^a ,
Xu Kang-Ping ^b ,
Tan Gui-Shan ^a,b,*,,

a.
Xiangya Hospital of Central South University, Changsha 410008, China
b.
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China

Corresponding author: Tan Gui-Shan, tgs395@aliyun.com

Received Date: 30 November 2016
Revised Date: 18 January 2017
Accepted Date: 21 February 2017
Available Online: 9 July 2017

Figures(2)

Three new carboxylated flavonoids, uncinatic acids A-C (1-3), were isolated from the whole herb of Selaginella uncinata. Their structures were established on the basis of extensive NMR analysis including 1D, 2D NMR experiments and HR-ESIMS techniques. All of them share the carboxylation structural characteristic. Compounds 1 and 2 belong to novel naturally occuring furanoflavonoids which is firstly reported in genus Selaginella. Such furanoflavonoids with dicarboxylic acid structrure have never been discovered before. In addition, the isolates were tested for their cytotoxicity against A549 and BGC-823 cell lines in vitro.
- Selaginella uncinata,
- Selaginella,
- Uncinatic acids A-C,
- Carboxylated flavonoids,
- Furanoflavonoids,
- Anticancer,
- Cytotoxicity
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沈阳化工大学材料科学与工程学院沈阳 110142