Citation: . Facile synthesis of CF₃-substituted dienamides via one-pot tandem reactions[J]. Chinese Chemical Letters, ;2017, 28(7): 1469-1472. doi: 10.1016/j.cclet.2017.02.017 shu

Facile synthesis of CF₃-substituted dienamides via one-pot tandem reactions

Received Date: 13 December 2016
Revised Date: 20 February 2017
Accepted Date: 28 February 2017
Available Online: 6 July 2017

Figures(3)

A one-pot reaction sequence of sequential phosphine-promoted tandem annulations of aryl trifluoromethyl ketones and MBH (Morita-Baylis-Hillman) carbonates and DBU-mediated aminolysis was developed. This method provides a step-economical approach to trifluoromethylated dienamides with diverse structural complexity from readily available starting materials in moderate yields.
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