Citation: Konkala Veera Swamy, Dubey Pramod Kumar. Sulfamic acid as a green, reusable catalyst for stepwise, tandem & one-pot solvent-free synthesis of pyrazole derivatives[J]. Chinese Chemical Letters, ;2017, 28(7): 1571-1576. doi: 10.1016/j.cclet.2017.02.005 shu

Sulfamic acid as a green, reusable catalyst for stepwise, tandem & one-pot solvent-free synthesis of pyrazole derivatives

Konkala Veera Swamy ,
Dubey Pramod Kumar ^,

Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, College of Engineering, Kukatpally 500085, India

Corresponding author: Dubey Pramod Kumar, veeruchem06@gmail.com
Received Date: 7 November 2016
Revised Date: 23 January 2017
Accepted Date: 13 February 2017
Available Online: 22 July 2017

Figures(7)

Sulfamic acid (SA) is a bi-functional, cost-effective and reusable green catalyst for the synthesis of 4-(pyrazol-4-yl)methylenepyrazol-5(4H)-one derivatives by one-pot, three-component condensation of pyrazol-4-carbaxaldehydes, β-ketoesters and phenyl hydrazine (Route-I). In addition to this method, another simple condensation of pyrazol-4-carbaxaldehydes with pyrazolone in the presence of SA under the solvent-free condition in good yield is reported. The merits of these protocols are mild conditions, non-aqueous workup, high yields, easy availability of the catalyst, no chromatographic separation and inexpensive solid acid catalyst. Furthermore, SA could be recycled and reused for five times without losing its catalytic activity.
- Pyrazol-4-carbaxaldehydes,
- Knoevenagel condensation,
- Sulfamic acid,
- Multicomponent reaction,
- Physical grinding
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