Citation: Chang Kang, Chen Jian-Qin, Shi Yan-Xia, Sun Mei-Jian, Li Peng-Fei, Zhao Zhen-Jiang, Zhu Wei-Ping, Li Hong-Lin, Xu Yu-Fang, Li Bao-Ju, Qian Xu-Hong. The discovery of new scaffold of plant activators: From salicylic acid to benzotriazole[J]. Chinese Chemical Letters, ;2017, 28(4): 919-926. doi: 10.1016/j.cclet.2017.02.004 shu

The discovery of new scaffold of plant activators: From salicylic acid to benzotriazole

a.
State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
b.
State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
c.
Institute of Vegetables and Flowers, Chinese Academy of Agricultural Science, Beijing 100081, China

Corresponding author: Xu Yu-Fang, yfxu@ecust.edu.cn Li Bao-Ju, libaoju@caas.cn Qian Xu-Hong, xhqian@ecust.edu.cn
Received Date: 21 October 2016
Revised Date: 20 December 2016
Accepted Date: 20 December 2016
Available Online: 13 June 2017

Figures(7)

Started from salicylic acid(SA)and related commercialized plant activators, based on molecular three-dimensional shape and pharmacophore similarity comparison(SHAFTS), a new lead compound benzotriazole was predicted and a series of benzotriazole derivatives were designed and synthesized.The bioassay showed that benzotriazole had high activity against a broad spectrum of diseases including fungi and oomycetes in vivo, but no activity in vitro.And the introduction of proper groups at the 1'-position and 5'-position was beneficial to the activity.So, they had the potential to be exploited as novel plant activators.
- Plant activator,
- Systemic acquired resistance,
- Salicylic acid,
- Benzotriazole,
- Virtual screening
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