Citation: . Bioactivity-based UPLC/Q-TOF/MS strategy for screening of anti-inflammatory components from Cimicifugae Rhizoma[J]. Chinese Chemical Letters, ;2017, 28(2): 476-481. doi: 10.1016/j.cclet.2016.11.021 shu

Bioactivity-based UPLC/Q-TOF/MS strategy for screening of anti-inflammatory components from Cimicifugae Rhizoma

Received Date: 30 September 2016
Revised Date: 8 November 2016
Accepted Date: 10 November 2016
Available Online: 22 February 2016

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In this study, the protective effects of Cimicifugae Rhizoma (CR) was demonstrated in Pseudomonas aeruginosa-induced pneumonia mouse model. To identify the anti-inflammatory ingredients, an ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS) integrated nuclear factor кB (NF-кB) luciferase reporter assay screening system was carried out. As a result, some caffeic acid derivatives, including caffeic acid, ferulic acid/isoferulic acid, fukinolic acid, and cimicifugic acid ingredients were identified as the potential effective compounds from CR. For testing the anti-inflammatory capacity, caffeic acid was demonstrated to inhibit NF-кB and reduce the levels of IL-6 and IL-8 in TNF-α-treated BEAS-2B cells in a dose-dependent manner. Hence, CR preparations and its cinnamic acid derivatives have the possibility to be developed as a complementary therapy in the treatment of respiratory system infection in clinics.
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