Citation: . Synthesis and biological activities of (E)-β-farnesene analogues containing 1,2,3-thiadiazole[J]. Chinese Chemical Letters, ;2017, 28(2): 372-376. doi: 10.1016/j.cclet.2016.10.030 shu

Synthesis and biological activities of (E)-β-farnesene analogues containing 1,2,3-thiadiazole

Received Date: 25 July 2016
Revised Date: 12 September 2016
Accepted Date: 6 October 2016
Available Online: 1 February 2016

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In order to discover novel compounds with high-activity to control aphid, a series of novel ((E)-β-farnesene analogues containing 1,2,3-thiadiazole were designed and synthesized, and their structures were confirmed by IR, ¹H NMR, ¹³C NMR, and HRMS (ESI). The stability of representative compounds was studied by HPLC and ¹H NMR techniques. Repellent activity results indicated that compounds 8h and 8j displayed 60.3% and 62.0% repellent rates, respectively. The aphicidal bioassay results showed that most analogues exhibited considerable aphicidal activity against Myzus persicae. Especially, analogues 8l, 8s and 8t exhibited high activity with LC₅₀ values of 33.4 μg/mL, 50.2 μg/mL and 61.8 μg/mL, respectively, which were higher than the lead compound (E)-β-farnesene, but lower than commercial insecticide pymetrozine with a LC₅₀ of 7.1 μg/mL.
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