Citation: . Synthesis and antitumor activity of some new pyrazolo[1,5-a] pyrimidines[J]. Chinese Chemical Letters, ;2017, 28(2): 388-393. doi: 10.1016/j.cclet.2016.10.022 shu

Synthesis and antitumor activity of some new pyrazolo[1,5-a] pyrimidines

Received Date: 25 July 2016
Revised Date: 1 September 2016
Accepted Date: 20 September 2016
Available Online: 23 February 2016

Figures(6)

New series of pyrazolo[1,5-a]pyrimidine derivatives 7a-i, 11a-c and Schiff bases 13a-c were synthesized and screened for their in vitro antitumor activity against three human carcinoma cell lines, namely colorectal carcinoma (HCT116), prostate adenocarcinoma (PC-3) and liver carcinoma (HepG-2) using MTT cytotoxicity assay at 100 μg/mL. Some of the tested compounds displayed good anticancer activities against HCT-116 and PC-3 cells. Whereas, compounds 7d and 11a showed better antitumor activity than the rest of the compounds against both cell lines. A structure-activity relationship (SAR) has been discussed and structures of the newly synthesized compounds were confirmed by different spectral data (MS, IR, ¹H NMR and ¹³C NMR) and elemental analysis.
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