Citation: Lin Peng-Cheng, Yao Jing, Wu Jiang, Tian Jin, Bao Yi, Lin Sheng. A new ureido-substituted amino acid from the tubers of Gymnadenia conopsea[J]. Chinese Chemical Letters, ;2017, 28(2): 257-259. doi: 10.1016/j.cclet.2016.08.005 shu

A new ureido-substituted amino acid from the tubers of Gymnadenia conopsea

Lin Peng-Cheng ^a ,
Yao Jing ^a ,
Wu Jiang ^a ,
Tian Jin ^a ,
Bao Yi ^a ,
Lin Sheng ^a,b,,

a.
College of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining 810000, China
b.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

Corresponding author: Lin Sheng, lsznn@imm.ac.cn
Received Date: 2 June 2016
Revised Date: 13 July 2016
Accepted Date: 7 August 2016
Available Online: 3 February 2016

Figures(2)

A new ureido-substituted amino acid, conopsamide A (1), has been isolated from an ethanolic extract of the tubers of Gymnadenia conopsea. Its structure was elucidated by extensive spectroscopic analysis, and the absolute configuration was assigned by Marfey's method. The new compound was evaluated for in vitro assay for HDAC1 (Histone Deacetylase 1) inhibitory activity.
- Gymnadenia conopsea,
- Orchidaceae,
- Ureido-substituted amino acid,
- HDAC1 inhibitory activity
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沈阳化工大学材料科学与工程学院沈阳 110142