Citation: Xu Zhi, Zhang Shu, Gao Chuan, Fan Jing, Zhao Feng, Lv Zao-Sheng, Feng Lian-Shun. Isatin hybrids and their anti-tuberculosis activity[J]. Chinese Chemical Letters, ;2017, 28(2): 159-167. doi: 10.1016/j.cclet.2016.07.032 shu

Isatin hybrids and their anti-tuberculosis activity

Xu Zhi ^a,1 ,
Zhang Shu ^b,1 ,
Gao Chuan ^c ,
Fan Jing ^d ,
Zhao Feng ^c ,
Lv Zao-Sheng ^a,, ,
Feng Lian-Shun ^a,c,e,,

a.
Wuhan University of Science and Technology, 430081, China
b.
Pony Testing International Group, Wuhan 430034, China
c.
WuXi AppTec, Wuhan 430075, China
d.
Hengshui University, Hengshui 053000, China
e.
Synthetic and Functional Biomolecules Center, Peking University, Beijing 100871, China

Corresponding author: Lv Zao-Sheng, lzs1961@yahoo.com.cn Feng Lian-Shun, ochemistry@163.com

Received Date: 16 May 2016
Revised Date: 12 July 2016
Accepted Date: 17 July 2016
Available Online: 9 February 2016

Figures(17)

Tuberculosis (TB) is one of the most common and even fatal infectious diseases known to mankind. Millions of new cases are reported every year over the world, and one-third of the world's population is potentially infected with mycobacteria tuberculosis (MTB). Research to develop novel anti-TB drugs led to the identification of several isatin-based antimycobacterial agents, among which a number of potential candidates displayed excellent antimycobacterial activity and were found to be free of cytotoxicity. This review outlines the advances in the application of isatin hybrids as antimycobacterial agents and the critical aspects of design and structure-activity relationship of these derivatives.
- Isatin hybrids,
- Mycobacterium tuberculosis,
- Quinolone,
- Structure-activity relationship,
- Review
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