Citation: Sai Chun-Mei, Qin Ning-Bo, Jia Cui-Cui, Li Da-Hong, Wang Kai-Bo, Pei Yue-Hu, Bai Jiao, Li Zhan-Lin, Hua Hui-Ming. Macleayine, a new alkaloid from Macleaya cordata[J]. Chinese Chemical Letters, ;2016, 27(11): 1717-1720. doi: 10.1016/j.cclet.2016.06.017 shu

Macleayine, a new alkaloid from Macleaya cordata

Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China

Corresponding author: Li Zhan-Lin, lzl1030@hotmail.com Hua Hui-Ming, huimhua@163.com
Received Date: 20 May 2016
Revised Date: 26 May 2016
Accepted Date: 3 June 2016
Available Online: 17 November 2016

Figures(5)

Macleayine (1), a new natural occurring alkaloid with a unique spiro[furanone-piperidinedione] framework, was isolated from the aerial parts of Macleaya cordata.Its unusual structure was established by extensive spectroscopic analyses, computer-assisted structure elucidation software (ACD/Structure Elucidator), quantum chemistry calculations and ECD calculation.The result of virtual molecular docking predicted the compound can enhance the effects of insulin, and may be used to treat type Ⅱ diabetes.
- Macleayine,
- A natural occurring alkaloid,
- Quantum chemistry calculations,
- ECD calculation,
- Plausible biogenetic pathway,
- Macleaya cordata
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