Citation: Shi-Guo Zhang, Zong-Bo Xie, Lian-Sheng Liu, Meng Liang, Zhang-Gao Le. Synthesis of 2, 3-dihydroquinazolin-4(1H)-ones catalyzed by α-chymotrypsin[J]. Chinese Chemical Letters, ;2017, 28(1): 101-104. doi: 10.1016/j.cclet.2016.06.001 shu

Synthesis of 2, 3-dihydroquinazolin-4(1H)-ones catalyzed by α-chymotrypsin

a.
Jiangxi 2011 Joint Center for the Innovative Mass Spectrometry and Instrumentation, East China University of Technology, Nanchang 330013, China
b.
School of Chemistry, Biology and Material Science, East China University of Technology, Nanchang 330013, China

Corresponding author: Zong-Bo Xie, zbxie@ecit.cn Zhang-Gao Le, zhgle@ecit.cn
Received Date: 19 February 2016
Revised Date: 3 May 2016
Accepted Date: 16 May 2016
Available Online: 7 January 2016

Figures(1)

We discovered that α-chymotrypsin has a promiscuous ability to catalyze the cyclocondensation of aromatic and aliphatic aldehydes with 2-aminobenzamides to afford the corresponding 2, 3-dihydroquinazolin-4(1H)-ones successfully in high yields (90%-98%) under alcohol solvent. The catalytic activity of α-chymotrypsin was evaluated through investigating the temperature, the enzyme loading and the ratio of substrates in the enzyme-catalyzed reactions. The present method proves to be efficient and environmentally friendly in terms of short reaction time, high yield, green catalyst and the clean products obtained without further purification processes.
- 2, 3-Dihydroquinazolin-4(1H)-ones,
- α-Chymotrypsin,
- Cyclocondensation,
- Biocatalysis,
- 2-Aminobenzamides
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