Citation: Hu Dong-Yan, Li Meng-Shun, Zhong Wen-Wu, Ji Jian-Xin, Zhu Jin, Wei Wei, Zhang Qiang, Cheng Ming. Direct synthesis of α-hydroxyketone phosphates from terminal alkynes and H-phosphine oxides in the presence of PhI(OAc)₂ and H₂O[J]. Chinese Chemical Letters, ;2016, 27(11): 1691-1695. doi: 10.1016/j.cclet.2016.05.029 shu

Direct synthesis of α-hydroxyketone phosphates from terminal alkynes and H-phosphine oxides in the presence of PhI(OAc)₂ and H₂O

Hu Dong-Yan ^a,c ,
Li Meng-Shun ^a,c ,
Zhong Wen-Wu ^b,c ,
Ji Jian-Xin ^b ,
Zhu Jin ^a ,
Wei Wei ^d ,
Zhang Qiang ^b,, ,
Cheng Ming ^b,,

a.
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China
b.
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China
c.
University of the Chinese Academy of Sciences, Beijing 100049, China
d.
School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China

Corresponding author: Zhang Qiang, zhangqiang@cib.ac.cn Cheng Ming, chengming198101@163.com
Received Date: 1 April 2016
Revised Date: 4 May 2016
Accepted Date: 10 May 2016
Available Online: 3 November 2016

Figures(6)

A simple and highly efficient one-pot method for the construction of α-hydroxyketone phosphates from terminal alkynes and H-phosphine oxides has been developed in the presence of PhI (OAc)₂ and H₂O.The present protocol provides an attractive approach to α-hydroxyketone phosphates in good to high yields, with the advantages of operation simplicity, the use of commercially available materials, broad substrate scope, high atom efficiency and good tolerance to scale-up synthesis.
- α-Hydroxyketone phosphates,
- Alkynes,
- H-Phosphine oxides,
- Water,
- Phenyliodine diacetate
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沈阳化工大学材料科学与工程学院沈阳 110142

Direct synthesis of α-hydroxyketone phosphates from terminal alkynes and H-phosphine oxides in the presence of PhI(OAc)2 and H2O

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通讯作者: 陈斌, bchen63@163.com

Direct synthesis of α-hydroxyketone phosphates from terminal alkynes and H-phosphine oxides in the presence of PhI(OAc)₂ and H₂O