Citation: Zhou Chen-Feng, Li Jian-Jun, Su Wei-Ke. Morpholine triflate promoted one-pot, four-component synthesis of dihydropyrano[2, 3-c] pyrazoles[J]. Chinese Chemical Letters, ;2016, 27(11): 1686-1690. doi: 10.1016/j.cclet.2016.05.010 shu

Morpholine triflate promoted one-pot, four-component synthesis of dihydropyrano[2, 3-c] pyrazoles

Zhou Chen-Feng ^a,b ,
Li Jian-Jun ^a,b,, ,
Su Wei-Ke ^a,,

a.
National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China
b.
Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China

Corresponding author: Li Jian-Jun, lijianjun@zjut.edu.cn Su Wei-Ke, pharmlab@zjut.edu.cn
Received Date: 9 March 2016
Revised Date: 4 May 2016
Accepted Date: 10 May 2016
Available Online: 25 November 2016

Figures(3)

A one-pot, four-component reaction of ethyl acetoacetate, hydrazine hydrate, aldehydes, and malononitrile was discussed using Lewis acid catalyst morpholine triflate (MorT) to afford a series of dihydropyrano[2, 3-c] pyrazoles, which were generally catalyzed by organic alkalis.Moderate to excellent yields, no chromatographic purification, and evasion of environmentally hazardous solvents in the reaction process make this protocol very useful for academia and industry.
- Dihydropyrano[2, 3-c] pyrazole,
- MCRs,
- Morpholine triflate,
- Green chemistry,
- Lewis acid
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