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Citation: Jun Ding, Ying Guo, Ling-Yan Shao, Fei-Yi Zhao, Dao-Hua Liao, Hong-Wei Liu, Ya-Fei Ji. Palladium-catalyzed multi-acetoxylation of 1,3-disubstituted 1H-pyrazole-5-carboxylates via direct C(sp2)-H or C(sp3)-H bond activation[J]. Chinese Chemical Letters, ;2016, 27(10): 1617-1621. doi: 10.1016/j.cclet.2016.04.007 shu

Palladium-catalyzed multi-acetoxylation of 1,3-disubstituted 1H-pyrazole-5-carboxylates via direct C(sp2)-H or C(sp3)-H bond activation

  • School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China

  • Corresponding author: Hong-Wei Liu, hwliu@ecust.edu.cn Ya-Fei Ji, jyf@ecust.edu.cn
  • Received Date: 10 March 2016
    Revised Date: 30 March 2016
    Accepted Date: 31 March 2016
    Available Online: 21 October 2016

Figures(2)

  • A palladium-catalyzed multi-acetoxylation of 1,3-disubstituted 1H-pyrazole-5-carboxylate derivatives containing multiple potential reactive sites is described. Therein, the sequence of this process has been appropriately investigated. The protocol mainly provides the di- and tri-acetoxylated products for 1,3-diarylpyrazoles. Besides, it is found that the acetoxylation of C(sp3)-H bond is prior to that of C(sp2)-H bond under structurally competitive conditions.
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