Citation: Tian-Yi Li, Hua-Chao Chen, Yi-Ming Jing, Hua-Bo Han, Xiao Liang, You-Xuan Zheng, Wei-Jiang He. Cyclometallated iridium phosphors with amino acid ancillary ligand for intracellular imaging[J]. Chinese Chemical Letters, ;2016, 27(10): 1582-1585. doi: 10.1016/j.cclet.2016.04.004 shu

Cyclometallated iridium phosphors with amino acid ancillary ligand for intracellular imaging

State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Advanced Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China

Corresponding author: You-Xuan Zheng, yxzheng@nju.edu.cn Wei-Jiang He, heweij69@nju.edu.cn
Received Date: 13 January 2016
Revised Date: 28 March 2016
Accepted Date: 1 April 2016
Available Online: 20 October 2016

Figures(4)

Two new iridium complexes, (dfppy)₂Ir(L-alanine) (dfppy=2-(2, 4-difluorophenyl)pyridine) and (piq)₂Ir(L-alanine) (piq=L-phenylisoquinoline) were prepared with L-alanine as ancillary ligand. The two complexes show bright greenish-blue and red emission respectively. Theoretic study demonstrated that the emission nature of these complexes is mainly determined by the main ligand. And their improved aqueous solubility and the retained quantum yield favor their application in cell imaging. Intracellular imaging suggested that these two complexes have fine cell membrane permeability and is mainly distributed in cytoplasm. This study displayed a new strategy to design aqueous soluble phosphorescent cyclometallated Ir(Ⅲ) complex via introducing amino acid as ancillary ligand.
- Iridium complex,
- L-Alanine,
- Water solubility,
- Phosphorescent materials,
- Cell imaging
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