Citation: Xue-Mei Li, Rui-Rui Zhao, Yu-Ling Wei, Dan Yang, Zhang-Jian Zhou, Jun-Feng Zhang, Ying Zhou. A rhodamine derivative for Hg²⁺-selective colorimetric and fluorescent sensing and its application to in vivo imaging[J]. Chinese Chemical Letters, ;2016, 27(6): 813-816. doi: 10.1016/j.cclet.2016.04.001 shu

A rhodamine derivative for Hg²⁺-selective colorimetric and fluorescent sensing and its application to in vivo imaging

a Department of Safety Evaluation, Technology Center of China Tobacco Yunnan Industrial Co., Ltd., Kunming 650106, China;
b College of Chemical Science and Technology, Yunnan University, Kunming 650091, China;
c College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China

Received Date: 2 February 2016
Revised Date: 15 March 2016

Fund Project: This work was supported by the fund of China Tobacco Yunnan Industrial Co. (No. 2015JC05), the Foundation of the Department of Science and Technology of Yunnan Province of China (Nos. 2013HB062, 2014HB008), and Training Project (No. XT412003) of Yunnan University.

A rhodamine-based sensor has been developed for the detection of mercuric ions. The colorimetric and fluorescence responses, allowing naked-eye detections, are based on Hg²⁺-induced opening of the rhodamine spirocycle. Among all the testes ions, only Hg²⁺ generated a significant fluorescence enhancement of up to 30'-fold, with a bright yellow-green emission. This sensor was a low toxic compound, and was successfully applied in the in vivo imaging of Hg²⁺ in Spill 2 cells and C. elegans. This approach provides a sensitive and accurate method for the estimation of Hg²⁺ in environmental, tobacco and biological applications.
- Chemsensor,
- Mercury,
- Rhodamine,
- Colorimetric,
- Fluorescence,
- In vivo imaging
1. [1]
2. [2]
3. [3]
4. [4]
5. [5]
6. [6]
7. [7]
8. [8]
9. [9]
10. [10]
11. [11]
12. [12]
13. [13]
14. [14]
1. [1]
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3. [3]
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5. [5]
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6. [6]
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12. [12]
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13. [13]
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14. [14]
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15. [15]
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16. [16]
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17. [17]
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18. [18]
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19. [19]
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20. [20]
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