Citation: Shu-Qi Wang, Qing-Wei Zhang, Xiao-Ling Wang, Xia-Xia Di, Xiao-Ning Wang, Hong-Xiang Lou. Chemical constituents from Cicuta virosa Linnaeus and their reversal effects on doxorubicin-resistant human myelogenous leukemia (K562/A02) cells[J]. Chinese Chemical Letters, ;2016, 27(7): 1013-1016. doi: 10.1016/j.cclet.2016.03.039 shu

Chemical constituents from Cicuta virosa Linnaeus and their reversal effects on doxorubicin-resistant human myelogenous leukemia (K562/A02) cells

a.
School of Pharmaceutical Science, Shandong University, Jinan 250012, China
b.
Xintai Institute of Skin Diseases, Xintai 271200, China
c.
The Second Hospital of Shandong University, Jinan 250033, China
d.
Faculty of Pharmaceutical Sciences, School of Health Sciences, University of Iceland, Iceland

Corresponding author: Xiao-Ning Wang, wangxn@sdu.edu.cn Hong-Xiang Lou, louhongxiang@sdu.edu.cn
Received Date: 3 February 2016
Revised Date: 16 March 2016
Accepted Date: 22 March 2016
Available Online: 2 July 2016

Figures(2)

Two new compounds, 11,11'-dimer of scopoletin (1) and 11-O-β-glucopyranosylhamaudol (2), together with seven known compounds were isolated and identified from the whole grass of Cicuta virosa. The chemical structures of the isolated compounds were elucidated using different spectroscopic methods. In addition, the chemical constituents were evaluated for multidrug resistance reversing activity towards doxorubicin-resistant K562/A02 cells. Compounds 1, 8, and 9 were endowed with remarkable MDR reversing effects.
- Cicuta virosa,
- MDR,
- K562/A02,
- Doxorubicin,
- P-Glycoprotein
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1.
沈阳化工大学材料科学与工程学院沈阳 110142