Citation: Yu Fei, Wang Qi, Wang Han, Si Long-Long, Liu Jia-Xin, Han Xu, Xiao Su-Long, Zhang Li-He, Zhou De-Min. Synthesis and biological evaluation of echinocystic acid derivatives as HCV entry inhibitors[J]. Chinese Chemical Letters, ;2016, 27(5): 711-713. doi: 10.1016/j.cclet.2016.01.050 shu

Synthesis and biological evaluation of echinocystic acid derivatives as HCV entry inhibitors

Yu Fei ^a,, ,
Wang Qi ^b ,
Wang Han ^b ,
Si Long-Long ^b ,
Liu Jia-Xin ^a ,
Han Xu ^b ,
Xiao Su-Long ^b ,
Zhang Li-He ^b ,
Zhou De-Min ^b,,

a.
Medical Faculty of Kunming University of Science and Technology, Kunming 650500, China
b.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

Corresponding author: Yu Fei, feiyuz8@163.com Zhou De-Min, deminzhou@bjmu.edu.cn
Received Date: 26 June 2015
Revised Date: 14 December 2015
Accepted Date: 23 January 2016
Available Online: 6 May 2016

Figures(4)

A series of echinocystic acid (EA) 28-COOH derivatives was synthesized, and their anti-HCV entry activity was evaluated by HCVpp and VSVpp entry assay. It was found that some of them showed moderate anti-HCV entry activity, especially compound 12, and these modifications also removed the undesired hemolytic effect.
- Triterpene,
- Echinocystic acid,
- HCV entry inhibitors,
- Hemolysis
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