Citation: Manisha R. Bhosle, Lalit D. Khillare, Sambhaji T. Dhumal, Ramrao A. Mane. A facile synthesis of 6-amino-2H, 4H-pyrano[2,3-c]pyrazole-5-carbonitriles in deep eutectic solvent[J]. Chinese Chemical Letters, ;2016, 27(03): 370-374. doi: 10.1016/j.cclet.2015.12.005 shu

A facile synthesis of 6-amino-2H, 4H-pyrano[2,3-c]pyrazole-5-carbonitriles in deep eutectic solvent

1.
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004, Maharashtra, India

Corresponding author: Ramrao A. Mane,
Received Date: 7 September 2015
Available Online: 26 October 2015

A convenient synthesis of 6-amino-2H,4H-pyrano[2,3-c]pyrazole-5-carbonitriles has been accomplished by one pot four-component cyclocondensation of aromatic aldehydes (1a-o) malanonitrile (2), ethyl acetoacetate (3), and hydrazine hydrate (4) in freshly prepared deep eutectic solvent, DES (choline chloride:urea). This protocol has afforded corresponding pyrano[2,3-c]pyrazoles in shorter reaction time with high yields, and it avoids the use of typical toxic catalysts and solvents.
- Choline chloride,
- Cyclocondensation,
- DES,
- One pot,
- Urea,
- Pyranopyrazoles
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