Citation: Hong-Kun Yang, Yuan-Feng Tong, Song Wu. A novel and efficient strategy involving a CuI catalyzed cascade reaction to synthesize acenaphtho[1,2-b]quinoline derivatives[J]. Chinese Chemical Letters, ;2016, 27(03): 349-352. doi: 10.1016/j.cclet.2015.11.011 shu

A novel and efficient strategy involving a CuI catalyzed cascade reaction to synthesize acenaphtho[1,2-b]quinoline derivatives

1.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Corresponding author: Song Wu,
Received Date: 9 October 2015
Available Online: 24 October 2015
Fund Project: We gratefully acknowledge the National Key Technology R&D Program "New Drug Innovation" of China (No.2013ZX09402103) (No.2013ZX09402103)

A novel and efficient approach for the straightforward synthesis of biologically significant acenaphtho[1,2-b]quinoline derivatives in good yields utilizing CuI as a catalyst with a broad array of substrates has been developed. The strategy features as a CuI-catalyzed cascade reaction involving the formation of two new C-C bonds and one new C-N bond with high atom economy. A proposed mechanism for the reaction is described.
- Cascade reaction,
- CuI,
- Substituted anilines,
- Phenylethynyl-1-naphthaldehydes,
- Acenaphtho[1,2-b]quinolones
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