Citation: Yue-Ping Jiang, Qing-Lan Guo, Yu-Feng Liu, Jian-Gong Shi. Codonopiloneolignanin A, a polycyclic neolignan with a new carbon skeleton from the roots of Codonopsis pilosula[J]. Chinese Chemical Letters, ;2016, 27(01): 55-58. doi: 10.1016/j.cclet.2015.11.009 shu

Codonopiloneolignanin A, a polycyclic neolignan with a new carbon skeleton from the roots of Codonopsis pilosula

1.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

Corresponding author: Jian-Gong Shi,
Received Date: 14 July 2015
Available Online: 6 August 2015
Fund Project: Financial support from the National Natural Science Foundation of China(Nos. 30825044, 21132009) (Nos. 30825044, 21132009) and the National Science and Technology Project of China(Nos. 2012ZX09301002-002, 2011ZX09307-002-01) are acknowledged. (PCSIRT, No. IRT1007)

A neolignan codonopiloneolignanin A(1) with a novel 2,9:2',9:7,7'-tricyclo-8,'-neolignane skeleton was isolated from an aqueous extract of the Codonopsis pilosula roots. Its structure including the absolute configuration was elucidated by extensive spectroscopic analysis, including 2D NMR and electronic circular dichroism calculation. The proposed biosynthetic pathway of compound 1 is also discussed.
- Codonopsis pilosula,
- Campanulaceae,
- Neolignan,
- 2,9:2',9:7,7'-Tricyclo-8,9'-neolignane,
- Codonopiloneolignanin A
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