Citation: Li-Yuan Zhang, Bao-Lei Wang, Yi-Zhou Zhan, Yan Zhang, Xiao Zhang, Zheng-Ming Li. Synthesis and biological activities of some fluorine-and piperazine-containing 1,2,4-triazole thione derivatives[J]. Chinese Chemical Letters, ;2016, 27(01): 163-167. doi: 10.1016/j.cclet.2015.09.015 shu

Synthesis and biological activities of some fluorine-and piperazine-containing 1,2,4-triazole thione derivatives

1.
State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin 300071, China

Corresponding author: Bao-Lei Wang, Zheng-Ming Li,
Received Date: 22 April 2015
Available Online: 10 July 2015
Fund Project: This work was supported by the National Natural Science Foundation of China(No. 21372133) (No. 21372133)"111" Project of Ministry of Education of China(No. B06005). (No. B06005)

A series of fluorine-and piperazine-containing 1,2,4-triazole thione derivatives were synthesized by the Mannich reaction of triazole intermediates with various substituted piperazines and formaldehyde in high yields. Structures of title compounds were confirmed by melting points, IR, ¹H NMR, ¹³C NMR and elemental analysis. The preliminary bioassays for 17 novel title compounds showed that several compounds have significant fungicidal activity against Cercospora arachidicola, Physalospora piricola and Rhizoctonia cerealis at 50μg/mL.
- Triazole thione derivatives,
- Fluorine,
- Piperazine,
- Mannich base,
- Biological activity
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