Citation: Aamer Saeed, Pervaiz Ali Channar, Qasir Iqbal, Jamaluddin Mahar. C-H Arylation using acyl thiourea ligands:Applications in the synthesis of 3,6-diaryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles[J]. Chinese Chemical Letters, ;2016, 27(01): 37-40. doi: 10.1016/j.cclet.2015.09.011 shu

C-H Arylation using acyl thiourea ligands:Applications in the synthesis of 3,6-diaryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles

1.
Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan

Corresponding author: Aamer Saeed,
Received Date: 17 June 2015
Available Online: 5 August 2015

Synthesis of a series of new 3,6-diaryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles(5a-o) was achieved by phophine free, C-H arylative cross-coupling of 6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles(4a-o) with suitably substituted iodoanilines using 1-(2-naphthoyl)-3-(4-bromophenyl)thiourea as a ligand. The requisite triazolothiadiazoles(4a-o) were obtained by the condensation of 4-amino-1,2,4-triazole-3-thiol(3) with suitably substituted aromatic acids in the presence of phosphoryl chloride.
- [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazoles,
- Acyl thiourea,
- C-H arylative coupling,
- N,N-Dimethylacetamide
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沈阳化工大学材料科学与工程学院沈阳 110142