Citation: Santhisudha Sarva, Jayaprakash Soora Harinath, Siva Prasad Sthanikam, Selvarajan Ethiraj, Mohanasrinivasan Vaithiyalingam, Suresh Reddy Cirandur. Synthesis, antibacterial and anti-inflammatory activity of bis(indolyl)methanes[J]. Chinese Chemical Letters, ;2016, 27(01): 16-20. doi: 10.1016/j.cclet.2015.08.012 shu

Synthesis, antibacterial and anti-inflammatory activity of bis(indolyl)methanes

1.
a Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, India;
2.
b School of Biosciences and Technology, VIT University, Vellore 632014, India

Corresponding author: Suresh Reddy Cirandur,
Received Date: 15 January 2015
Available Online: 21 May 2015

A series of bioactive bis(indolyl)methanes are synthesized by one-pot green reaction of indole with various substituted aldehydes by microwave irradiation under solvent free conditions. The antibacterial activity against Staphylococcus aureus and anti-inflammatory activity of the synthesized bis(indolyl)-methanes are evaluated in vitro and compared to standard drugs tetracycline and diclofenac, respectively. The majority of the compounds showed good antibacterial and anti-inflammatory activity. Interestingly, compounds 3j, 3i, 3k and 3g exhibited much higher anti-inflammatory activity than the standard diclofenac drug and thus qualify for clinical trials to be used as an anti-inflammatory compound.
- Bis(indolyl)methanes,
- Microwave irradiation,
- Antibacterial activity,
- Anti-inflammatory activity
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