Citation: Xin-Xin Qi, Zhen-Zhen Song, Jin-Long Gong, Zheng-Yu Fang, Xiao-Feng Wu. Synthesis of quinazolinones from o-aminobenzamides and benzyl amines under metal-free conditions[J]. Chinese Chemical Letters, ;2016, 27(01): 21-24. doi: 10.1016/j.cclet.2015.08.003 shu

Synthesis of quinazolinones from o-aminobenzamides and benzyl amines under metal-free conditions

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a Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou 310018, China;
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b Department of Anal-colorectal Surgery, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China;
c Leibniz-Institut für Katalyse e.
c Leibniz-Institut für Katalyse e. V. an der Universit ät Rostock, 18059 Rostock, Germany

Corresponding author: Xiao-Feng Wu,
Received Date: 27 May 2015
Available Online: 2 July 2015
Fund Project: Education Department of Zhejiang Province(No. Y201432060) (No. 14HASTIT017)Zhejiang Sci-Tech University(Nos. 1206838-Y and 14062015-Y) (in Science and Technology)

A convenient and transition-metal free protocol for quinazolinones synthesis with o-aminobenzamides and benzyl amines as substrates has been developed. Using H₂O₂ as the oxidant, various quinazolinones were obtained in moderate to good yields under metal-and additive-free conditions.
- Quinazolinones,
- Metal-free,
- Benzyl amine,
- H₂O₂
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