Citation: Zhen-Bang Lou, Xin-Long Pang, Chao Chen, Li-Rong Wen, Ming Li. Facile synthesis of 1-naphthols through a copper-catalyzed arylation of methyl ketones with o-bromoacetophenones[J]. Chinese Chemical Letters, ;2015, 26(10): 1231-1235. doi: 10.1016/j.cclet.2015.07.022 shu

Facile synthesis of 1-naphthols through a copper-catalyzed arylation of methyl ketones with o-bromoacetophenones

Zhen-Bang Lou ^1,2 ,
Xin-Long Pang ^1,2 ,
Chao Chen ^2,, ,
Li-Rong Wen ¹ ,
Ming Li ^1,,

1.
1 College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China;
2.
2 Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology(Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China

Corresponding author: Chao Chen, Ming Li,
Received Date: 15 May 2015
Available Online: 20 July 2015
Fund Project: This work was supported by National Natural Science Foundation of China (Nos. 21102080, 21372138) (Nos. 21102080, 21372138)Tsinghua University Initiative Scientific Research Program (No. 2011Z02150). (No. 2011Z02150)

The coupling reactions of simple methyl ketones with o-bromoacetophenones and subsquential cyclization reactions were realized to produce a range of 1-naphthols. These cascade reactions were initiated by a rare Cu-catalyzed arylation reaction of methyl ketones with aromatic bromides.
- Copper,
- Arylation,
- Ketones,
- Naphthol
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