Citation: Mei-Na Su, Jing Ye, Qi-Wei Li, Shui-Hong Li, Wei Ge, Xiao Chen, Hui Jiang, Xue-Mei Wang. Novel in situ biosynthesized fluorescent zinc nanoclusters for specific cellular bio-imaging[J]. Chinese Chemical Letters, ;2015, 26(11): 1400-1402. doi: 10.1016/j.cclet.2015.07.021 shu

Novel in situ biosynthesized fluorescent zinc nanoclusters for specific cellular bio-imaging

1.
State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China

Corresponding author: Xue-Mei Wang,
Received Date: 7 June 2015
Available Online: 16 July 2015

It is well known that zinc ions play an indispensable role in the structure and function of a large number of biological process and relevant bio-macromolecules. When some cancers occurred, the relevant concentration of zinc ions considerably decreased. Since cancer cells have a completely different redox homeostasis from normal cells, in this contribution, we have explored the possibility of bio-imaging or labeling of cancer cells through the in situ biosynthesized zinc nanoclusters by cancerous cells. The results demonstrate that we can readily realize the in vivo fluorescent bio-imaging of cancer cells through the in situ biosynthesis of the biocompatible zinc nanoclusters from cancerous cells (i.e., Hela cervical carcinoma cell line and others) when target cells cultured with micromolar zinc gluconate solutions.
- Flourescent bio-imaging of cancer cells
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沈阳化工大学材料科学与工程学院沈阳 110142