Citation: Gang Shan, Gui-Yi Huang, Yu Rao, Hui Zhang. Palladium-catalyzed ortho-selective C-H bond chlorination of aromatic ketones[J]. Chinese Chemical Letters, ;2015, 26(10): 1236-1240. doi: 10.1016/j.cclet.2015.07.011 shu

Palladium-catalyzed ortho-selective C-H bond chlorination of aromatic ketones

Gang Shan ² ,
Gui-Yi Huang ^1,2 ,
Yu Rao ^2,, ,
Hui Zhang ^1,,

1.
1 School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China;
2.
2 MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing 100084, China

Corresponding author: Yu Rao, Hui Zhang,
Received Date: 25 April 2015
Available Online: 24 June 2015
Fund Project: This work was supported by '973' grant (Nos. 2011CB965300) (Nos. 2011CB965300) NSFC (Nos. 21142008, 21302106) (Nos. 21142008, 21302106)

A palladium-catalyzed ortho-selective C-H bond chlorination reaction for the preparation of 2-chloro aromatic ketones was described. Both electron-withdrawing and electron-donating groups on the aromatic rings are well tolerated under the optimized conditions. The 2-chloro aromatic ketones obtained by our method could be applied to synthesize the derivatives of 1H-indazole or benzo[d]isoxazole.
- Palladium catalysis,
- C-H chlorination,
- Aromatic ketones
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