Citation: Yu-Feng Liu, Ming-Hua Chen, Xiao-Liang Wang, Qing-Lan Guo, Cheng-Gen Zhu, Sheng Lin, Cheng-Bo Xu, Yue-Ping Jiang, Yu-Huan Li, Jian-Dong Jiang, Yan Li, Jian-Gong Shi. Antiviral enantiomers of a bisindole alkaloid with a new carbon skeleton from the roots of Isatis indigotica[J]. Chinese Chemical Letters, ;2015, 26(8): 931-936. doi: 10.1016/j.cclet.2015.05.052 shu

Antiviral enantiomers of a bisindole alkaloid with a new carbon skeleton from the roots of Isatis indigotica

1.
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;
2.
b Jining Medical University, Jining 272067, China;
3.
c Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

Corresponding author: Jian-Gong Shi,
Received Date: 2 April 2015
Available Online: 26 May 2015
Fund Project:

A pair of indole alkaloid enantiomers with a novel bisindolylacetamide skeleton, insatindibisindolamides A and B (1a and 1b), was isolated from an aqueous extract of Isatis indigotica roots. The enantiomers were separated by chiral HPLC. Their structures and absolute configurations were elucidated by extensive spectroscopic analysis, including 2D NMR, X-ray crystallography, and electronic CD (ECD) calculation. The proposed biosynthetic pathway and preliminary investigations of the biological activity of compounds 1a and 1b are also discussed.
- Isatis indigotica,
- Cruciferae,
- Bisindole alkaloid,
- Enantiomers,
- Antiviral activity
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