Citation: Jiu-Cun Chen, Jun-Zhi Li, Jian-Hua Liu, Li-Qun Xu. Amphiphilic poly(ethylene glycol)-b-poly(ethylene brassylate) copolymers: One-pot synthesis, self-assembly, and controlled drug release[J]. Chinese Chemical Letters, ;2015, 26(10): 1319-1321. doi: 10.1016/j.cclet.2015.05.050 shu

Amphiphilic poly(ethylene glycol)-b-poly(ethylene brassylate) copolymers: One-pot synthesis, self-assembly, and controlled drug release

Jiu-Cun Chen ^1,2,3,, ,
Jun-Zhi Li ^1,3 ,
Jian-Hua Liu ^1,3 ,
Li-Qun Xu ^1,3

1.
1 Institute for Clean Energy & Advanced Materials, Southwest University, Chongqing 400715, China;
2.
2 State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China;
3.
3 Chongqing Key Laboratory for Advanced Materials & Technologies of Clean Energies, Chongqing 400715, China

Corresponding author: Jiu-Cun Chen,
Received Date: 16 March 2015
Available Online: 14 May 2015
Fund Project: This work is financially supported by the Open Fund of State Key Laboratory of Medicinal Chemical Biology (Nankai University) under grant 20140523 and the Fundamental Research Funds for the Central Universities (Nos. SWU 113075 and XDJK2014B015). (Nankai University)

A set of amphiphilic poly(ethylene glycol)-b-poly(ethylene brassylate) (PEG-b-PEB) copolymers based on the PEB hydrophobic block was first synthesized by ring-opening polymerization of ethylene brassylate with an organic catalyst. The EB/PEGmolar ratios and reaction times were adjusted to achieve different chain lengths of PEB. Block copolymers that were characterized by ¹H NMR and GPC could selfassemble into multimorphological aggregates in aqueous solution, which were characterized by DLS and TEM. The hydrophobic doxorubicin (DOX) was chosen as a drug model and successfully encapsulated into the nanoparticles. The release kinetics of DOX were investigated.
- Poly(ethylene brassylate),
- Self-assembly,
- Nanoparticles,
- Controlled drug release
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