Citation: Chao Wang, Yan-Hong Jiang, Chao-Guo Yan. Convenient synthesis of spiro[indoline-3,4'-pyrano[2,3-c]pyrazole] and spiro[acenaphthyl-3,4'-pyrano[2,3-c]pyrazoles] via fourcomponent reaction[J]. Chinese Chemical Letters, ;2015, 26(7): 889-893. doi: 10.1016/j.cclet.2015.05.018 shu

Convenient synthesis of spiro[indoline-3,4'-pyrano[2,3-c]pyrazole] and spiro[acenaphthyl-3,4'-pyrano[2,3-c]pyrazoles] via fourcomponent reaction

1.
College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China

Corresponding author: Chao-Guo Yan,
Received Date: 3 March 2015
Available Online: 6 April 2015
Fund Project: This work was financially supported by the National Natural Science Foundation of China (No. 21172189) (No. 21172189)

The domino four-component reaction of hydrated hydrazine, dimethyl acetylenedicarboxylate, isatin and malononitrile or ethyl cycanoacetate in ethanol in the presence of triethylamine afforded the polysubstituted spiro[indoline-3,4'-pyrano[2,3-c]pyrazole] derivatives in satisfactory yields. Under similar conditions, the four-component reaction containing acenaphthenequinone also resulted in the spiro[acenaphthyl-3,4'-pyrano[2,3-c]pyrazole] in good yields.
- Multicomponent reaction,
- Spirooxindole,
- Pyrano[2,3-c]pyrazole,
- Isatin,
- Acenaphthenequinone
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