Citation: Xue-Xian Chen, Li-Ming Yuan. Colorimetric enantiodiscrimination of mandelic acid by indicator displacement assay[J]. Chinese Chemical Letters, ;2015, 26(8): 1019-1021. doi: 10.1016/j.cclet.2015.04.027 shu

Colorimetric enantiodiscrimination of mandelic acid by indicator displacement assay

Xue-Xian Chen ,
Li-Ming Yuan ^,

1.
School of Energy and Environment, Yunnan Normal University, Kunming 650500, China

Corresponding author: Li-Ming Yuan,
Received Date: 19 December 2014
Available Online: 27 March 2015
Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21165022). (No. 21165022)

The colorimetric enantiodiscrimination between mandelic acid and L-proline-Cu (II) is exploited to develop enantioselective indicator displacement assays. The sensitivity of the assay could be tuned by using a colorimetric indicator. The chromophoric ligand, pyrocatechol violet, effectively competes with the mandelic acid guest for open coordination sites on L-proline-Cu (II). The ΔA could be increased to 0.12 by changing the ratio of (+)-and (-)-mandelic acid concentrations that were found to be optimal from the displacement experiments. The resultant enantiomer excess versus ΔA relationship is linear. From the calibration curves, the absorbance values of the unknowns may be calculated for the enantiomeric excess value and the colorimetric enantiodiscrimination of mandelic acid can thus be obtained.
- Mandelic acid,
- Enantioselective,
- Indicator displacement assays,
- Colorimetric enantiodiscrimination
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沈阳化工大学材料科学与工程学院沈阳 110142