Citation: Mohamed S.A. El-Gaby, Jehan A. Micky, Nadia M. Saleh, Yousry A. Ammar, Heba S.A. Mohamed. Synthesis and spectroscopic characterization of novel 2-amino-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidine and pyrimido[1,2-a]pyrimidine derivatives[J]. Chinese Chemical Letters, ;2015, 26(6): 690-694. doi: 10.1016/j.cclet.2015.04.003 shu

Synthesis and spectroscopic characterization of novel 2-amino-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidine and pyrimido[1,2-a]pyrimidine derivatives

1.
a Chemistry Department, Faculty of Science, Al-Azhar University at Assiut, 71524 Assiut, Egypt;
2.
b Chemistry Department, Faculty of Science (Girl's), Al-Azhar University, Nasr City, Cairo, Egypt;
3.
c Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt;
4.
d Photochemistry Department, National Research Center, El-Dokki, Giza, Egypt

Corresponding author: Mohamed S.A. El-Gaby,
Received Date: 1 December 2014
Available Online: 17 March 2015

2-Aminocyclopenta[d]pyrimidines 3a-c were achieved via a one-pot, three-component reactions of cyclopentanone 1, aromatic aldehyde and guanidine hydrochloride (1:2:1 molar ratio). Also, cyclization of 2,5-bis-(arylmethylidene)cyclopentanones 2 with guanidine hydrochloride (1:1 molar ratio) in methanol in the presence of sodiummethoxide afforded cyclopenta-[d]pyrimidines 3. Compound 3a has been shown to be a useful building block for the synthesis of some novel pyrimido[1,2-a]pyrimidines 5, 7 and 12. The structures of the newly synthesized compounds were confirmed on the basis of analytical and spectral data.
- Multicomponent reaction,
- Cyclopenta[d]pyrimidine,
- Pyrimido[1,2-a]pyrimidine,
- Cyclopentanone
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