Citation: Jin-Hong Liu, Zi-Fei Zhu, Jia Tang, Ai-Qin Jiang, Liu-Fang Hu, Li Chen. Novel NO-releasing derivatives of betulinic acid with antitumor activity[J]. Chinese Chemical Letters, ;2015, 26(6): 759-762. doi: 10.1016/j.cclet.2015.04.002 shu

Novel NO-releasing derivatives of betulinic acid with antitumor activity

Jin-Hong Liu ^a ,
Zi-Fei Zhu ^a ,
Jia Tang ^a ,
Ai-Qin Jiang ^b,, ,
Liu-Fang Hu ^a ,
Li Chen ^a,,

1.
a Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China;
2.
b Medical School of Nanjing University, Nanjing 210093, China

Corresponding author: Ai-Qin Jiang, Li Chen,
Received Date: 20 November 2014
Available Online: 17 March 2015

Thirteen novel NO-releasing derivatives of betulinic acid (BA) bearing two types of NO-donors (nitrates and furoxans) were synthesized and evaluated for their antitumor activity. The results showed that furoxan-based derivatives exhibited higher antitumor activity than nitrate-based derivatives, with compounds 11a and 11b displaying promising potency against B16 cell lines and HepG2 cell lines (IC₅₀ < 1 μmol/L). Wesupposed that NO-releasing amount of these derivatives which can be detected by Griess method may contribute more to their antitumor activity. As a result, furoxan-based derivatives released larger amount of NO than that of nitrate-based derivatives, which partially explained the higher anti-tumor activity of the former.
- Betulinic acid (BA),
- Derivatives,
- NO-releasing,
- Anti-tumor,
- NO donors
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沈阳化工大学材料科学与工程学院沈阳 110142