Citation: Ling-Hong Meng, Xiao-Ming Li, Yang Liu, Bin-Gui Wang. Polyoxygenated dihydropyrano[2,3-c]pyrrole-4,5-dione derivatives from the marine mangrove-derived endophytic fungus Penicillium brocae MA-231 and their antimicrobial activity[J]. Chinese Chemical Letters, ;2015, 26(5): 610-612. doi: 10.1016/j.cclet.2015.01.024 shu

Polyoxygenated dihydropyrano[2,3-c]pyrrole-4,5-dione derivatives from the marine mangrove-derived endophytic fungus Penicillium brocae MA-231 and their antimicrobial activity

1.
a Jiangxi Key Labrotory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China;
2.
b College of Science, Jiangxi Agricultural University, Nanchang 330045, China

Corresponding author: Bin-Gui Wang,
Received Date: 13 November 2014
Available Online: 12 January 2015
Fund Project: Financial support from the National Natural Science Foundation of China (No. 31270403) (No. 31270403)

A new polyoxygenated dihydropyrano[2,3-c]pyrrole-4,5-dione derivative, pyranonigrin F (1), together with a related known compound, pyranonigrin A (2), were isolated and identified from Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these metabolites were determined based on comprehensive spectral interpretation and the absolute configuration of compound 1 was established by X-ray crystallographic analysis. Compounds 1, and 2 showed potent activity against a broad spectrum of human-, aqua-, and plant-pathogens.
- Mangrove-derived fungus,
- Penicillium brocae,
- Secondary metabolites,
- Pyranonigrin F,
- Antibacterial activity
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沈阳化工大学材料科学与工程学院沈阳 110142