Citation: Ayyakannu Arumugam Napoleon, Fazlur-Rahman Nawaz Khan, Euh Duck Jeong, Eun Hyuk Chung. Potential anti-tubercular agents: Hexahydro-3-phenyl indazol-2-yl(pyridin-4-yl)methanones from anti-tubercular drug isoniazid and bis(substituted-benzylidene)cycloalkanones[J]. Chinese Chemical Letters, ;2015, 26(5): 567-571. doi: 10.1016/j.cclet.2015.01.008 shu

Potential anti-tubercular agents: Hexahydro-3-phenyl indazol-2-yl(pyridin-4-yl)methanones from anti-tubercular drug isoniazid and bis(substituted-benzylidene)cycloalkanones

1.
a Organic and Medicinal Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT-University, Vellore 632 014, India;
2.
b Korea Basic Science Institute, Busan Center, Busan 618 230, South Korea

Corresponding author: Fazlur-Rahman Nawaz Khan, Euh Duck Jeong,
Received Date: 2 November 2014
Available Online: 18 December 2014

A series of indazol-2-yl(pyridin-4-yl)methanones, 4 were acquired from 2,6-bisbenzylidene cyclohexanones, 3 and anti-tubercular drug (isoniazid), and their anti-tubercular impacts were screened. Among the test compounds used against Mycobacterium tuberculosis H37 Ra cell line in the microplate alamar blue assay, the compounds 4g-j revealed moderate anti-tubercular activity with MIC 12.5 μg/mL, comparable to standard drugs (streptomycin, MIC, 6.25 μg/mL, pyrazinamide, isoniazid and ciprofloxacin with MICs of 3.125 μg/mL).
- Benzylidene cyclohexanones,
- Hexahydro-3-phenyl indazol-2-yl (pyridin-,
- 4-yl)methanones,
- Isoniazid,
- Anti-tubercular activity
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