Citation: Qun Cai, Mei-Cai Liu, Bi-Ming Mao, Xuan Xie, Feng-Cheng Jia, Yan-Ping Zhu, An-Xin Wu. Direct one-pot synthesis of zolimidine pharmaceutical drug and imidazo[1,2-a]pyridine derivatives via I₂/CuO-promoted tandem strategy[J]. Chinese Chemical Letters, ;2015, 26(7): 881-884. doi: 10.1016/j.cclet.2014.12.016 shu

Direct one-pot synthesis of zolimidine pharmaceutical drug and imidazo[1,2-a]pyridine derivatives via I₂/CuO-promoted tandem strategy

1.
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China

Corresponding author: An-Xin Wu,
Received Date: 4 November 2014
Available Online: 22 November 2014
Fund Project:

An efficient one-pot synthetic protocol was developed for the synthesis of imidazo[1,2-a]pyridines from easily available starting materials: Aromatic ketones, α,β-unsaturated ketones, β-keto esters and 2- aminopyridines. The present reaction proceeded well in MeOH under the media of I₂/CuO. By using this method, themarketed drug zolimidine could be prepared easily with 95% yield. All these target products were characterized by NMR, HRMS and IR spectra. Furthermore, the target compound 3fa was determined by X-ray crystallographic analysis.
- 2-Aminopyridines,
- Aromatic ketones,
- Imidazo[1,2-a]pyridines,
- Zolimidine,
- One-pot
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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Direct one-pot synthesis of zolimidine pharmaceutical drug and imidazo[1,2-a]pyridine derivatives via I2/CuO-promoted tandem strategy

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通讯作者: 陈斌, bchen63@163.com

Direct one-pot synthesis of zolimidine pharmaceutical drug and imidazo[1,2-a]pyridine derivatives via I₂/CuO-promoted tandem strategy