Citation: Yan-Sha Gao, Li-Ping Wu, Kai-Xin Zhang, Jing-Kun Xu, Li-Min Lu, Xiao-Fei Zhu, Yao Wu. Electroanalytical method for determination of shikonin based on the enhancement effect of cyclodextrin functionalized carbon nanotubes[J]. Chinese Chemical Letters, ;2015, 26(5): 613-618. doi: 10.1016/j.cclet.2014.11.032 shu

Electroanalytical method for determination of shikonin based on the enhancement effect of cyclodextrin functionalized carbon nanotubes

Yan-Sha Gao ^a,b ,
Li-Ping Wu ^a ,
Kai-Xin Zhang ^a ,
Jing-Kun Xu ^a,, ,
Li-Min Lu ^b,, ,
Xiao-Fei Zhu ^a ,
Yao Wu ^a

1.
a Jiangxi Key Labrotory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China;
2.
b College of Science, Jiangxi Agricultural University, Nanchang 330045, China

Corresponding author: Jing-Kun Xu, Li-Min Lu,
Received Date: 10 January 2014
Available Online: 17 November 2014
Fund Project: We are grateful to the National Natural Science Foundation of China (No. 51302117) (No. 51302117) Postdoctoral Science Foundation of China (No. 2014M551857) (No. GJJ13258) and the Science and Technology Landing Plan of Universities in Jiangxi province (No. KJLD12081) for their financial support of this work. (No. 2014M551857)

A simple and sensitive electroanalytical method for determination of shikonin, a widely used antitumoral agent, using β-cyclodextrin-functionalized multiwalled carbon nanotubes composite modified glassy carbon electrodes (MWCNTs/β-CD/GCE) was presented. CDs are water-soluble and environmentally friendly and can improve the dispersibility of MWCNTs/β-CD functional materials, which was confirmed by SEM. The electrochemical behaviors of shikonin on different electrodes were investigated by cyclic voltammetry (CV) and differential pulse voltammograms (DPVs). The results demonstrated that the redox peak currents of shikonin obtained at MWCNTs/β-CD/GCE were much higher than those at the β-CD/GCE and MWCNTs/GCE, which can be attributed to the combination of the excellent electrocatalytic properties of MWCNTs and the molecular recognition ability of β-CD. At MWCNTs/β-CD/GCE, the response current exhibits a linear range from 5.0 nmol/L to 10.0 μmol/L with a detection limit of 1.0 nmol/L (S/N = 3). As a practical application, the proposed method was applied to quantitatively determine shikoninin urine samples with satisfying results.
- Shikonin,
- β-Cyclodextrin,
- Multiwalled carbon nanotubes,
- Modified electrode,
- Electrochemical detection
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