Citation: Peng Zhang, Xiao-Ming Li, Jia-Ning Wanga, Xin Li, Bin-Gui Wang. Prenylated indole alkaloids from the marine-derived fungus Paecilomyces variotii[J]. Chinese Chemical Letters, ;2015, 26(3): 313-316. doi: 10.1016/j.cclet.2014.11.020 shu

Prenylated indole alkaloids from the marine-derived fungus Paecilomyces variotii

Peng Zhang ^a,b ,
Xiao-Ming Li ^a ,
Jia-Ning Wanga ^b ,
^a,b ,
Xin Li ^a ,
Bin-Gui Wang ^,

1.
a Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China;
2.
b University of Chinese Academy of Sciences, Beijing 100049, China

Corresponding author: Bin-Gui Wang,
Received Date: 9 September 2014
Available Online: 2 November 2014
Fund Project: Financial support from the Natural Science Foundation of China (No. 31330009) (No. 31330009)

Two new prenylated indole alkaloids, namely, dihydrocarneamide A (1) and iso-notoamide B (2), were isolated from the marine-derived endophytic fungus Paecilomyces variotii EN-291. The structures of these metabolites were determined based on comprehensive spectral analysis, together with chiral HPLC analysis of the acidic hydrolysates. Unlike other prenylated indole alkaloids such as asperparalines, notoamides, and versicolamides, compounds 1 and 2 are the rare examples of C-5 prenylation, forming the fused dimethyldihydropyran ring at C-5 and C-6 of the indole ring. The cytotoxic activity of the isolated compounds was evaluated.
- Natural products,
- Indolediketopiperazine,
- Marine algal-derived fungus,
- Paecilomyces variotii,
- Cytotoxicity
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