Citation: Di Zhang, Da-Ming Zhang, Guang-Yang Xu, Jiang-Tao Sun. Copper-catalyzed 1,3-dipolar cycloaddition of methyleneindolinones and N,N'-cyclic azomethine imines[J]. Chinese Chemical Letters, ;2015, 26(3): 301-303. doi: 10.1016/j.cclet.2014.11.015 shu

Copper-catalyzed 1,3-dipolar cycloaddition of methyleneindolinones and N,N'-cyclic azomethine imines

1.
a Department of Chemical Engineering, Changzhou Institute of Engineering Technology, Changzhou 213164, China;
2.
b School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, China

Corresponding author: Jiang-Tao Sun,
Received Date: 25 August 2014
Available Online: 28 October 2014
Fund Project: We gratefully acknowledge the National Natural Science Foundation of China (No. 21172023) (No. 21172023) A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) (PAPD)

A copper-catalyzed stereoselective 1,3-dipolar cycloaddition of methyleneindolinones and N,N'-cyclic azomethine imines has been developed under mild reaction conditions. The spiro[pyrazolidin-3,3'-oxindoles] were obtained in moderate to high isolated yields (up to 82%) with good stereoselevtivities (up to 15:1) in the presence of 5 mol% of Cu(OAc)₂ at room temperature.
- Cycloaddition,
- Copper,
- Spiro compounds,
- Stereoselective synthesis
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沈阳化工大学材料科学与工程学院沈阳 110142